Evidence mapPaperPMID 41188231Full record

ArticleNature communications2025

Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes.

Yuta Yanagihara, Masatomo Takahashi, Yoshihiro Izumi, Tomofumi Kinoshita, Masaki Takao, Takeshi Bamba, Yuuki Imai

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuta YanagiharaDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon, Ehime, Japan.
Masatomo TakahashiDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-2493-2684
Yoshihiro IzumiDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-4608-4652
Tomofumi KinoshitaDepartment of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Masaki TakaoDepartment of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Takeshi BambaDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-7442-2738
Yuuki ImaiDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon, Ehime, Japan. y-imai@m.ehime-u.ac.jp.ORCID http://orcid.org/0000-0002-6119-0034

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP20K18066MEXT | Japan Society for the Promotion of Science (JSPS) JP23689066, JP15H04961, JP19H03786, and JP22H03203
6 · The paper itself

Abstract

Chondrocytes differentiated from mesenchymal stem cells play a role in determining skeletal patterns by ossification. However, the mechanism by which maintenance DNA methylation in chondrocytes regulates differentiation and skeletal formation is unclear. In the Musculoskeletal Knowledge Portal, Dnmt1 is significantly associated with Height. Long bones in Dnmt1-deficient (Dnmt1

Indexed as

ChondrocytesDNA (Cytosine-5-)-Methyltransferase 1Energy MetabolismGrowth PlateAnimalsCell DifferentiationCell ProliferationDNA MethylationMaleMiceMice, Inbred C57BLMice, KnockoutOsteogenesisDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouse

Identifiers

PMID41188231
PMCPMC12586564

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.