ArticleScientific reports2025
A sensitive green HPLC-fluorescence method for simultaneous analysis of sacubitril and valsartan in pure forms, pharmaceutical dosage form and human plasma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Green analytical evaluation of anticancer drug analysis: A multi-tool assessment of HPLC and LC-MS methods.Scientific reports · 2026Article
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3 authors.
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Abstract
The development of green methods of analysis has recently become a global trend in analytical chemistry, especially in routine HPLC analysis. This study presents a sensitive and economic green HPLC method with fluorescence detection for the simultaneous determination of sacubitril and valsartan in bulk, and pharmaceutical dosage forms in spiked human plasma using ibuprofen as an internal standard. Analysis was performed on a C18 column (150 mm × 4.6 mm, 5 mm) at ambient temperature with isocratic elution using 30 mM phosphate (pH 2.5) and ethanol in a ratio of (40:60 v/v) at a flow rate of 1.0 mL/min. The fluorescence detector was programmed for excitation and emission wavelengths from 0 to 3.2 min, where λ
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