ArticleDiabetology & metabolic syndrome2025
Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort study from the China health and retirement longitudinal study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association of high-sensitivity C-reactive protein-triglyceride glucose index and stroke outcomes: results from the China National Stroke Registry III.BMC neurology · 2026Article
- Joint association of TyG-ABSI composite index and inflammatory score with diabetes in middle-aged and older Chinese adults: a prospective cohort study from CHARLS (2011-2020).BMC endocrine disorders · 2026Article
- Differential associations between novel triglyceride-glucose-obesity indices and incident stroke in individuals with early-stage cardiovascular-kidney-metabolic syndrome: a longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Sex-Specific Associations of Triglyceride-Glucose Index and a Body Shape Index with Cardiometabolic Multimorbidity Risk: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Association between the newly proposed triglyceride glucose-a body shape index (TyG-ABSI) and atherosclerotic cardiovascular disease in the general population: modest diagnostic improvement compared with traditional TyG-related parameters.Cardiovascular diabetology · 2026Article
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7 authors.
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Abstract
objectiveRecent evidence suggests a strong association between triglyceride glucose-a body shape index (TyG-ABSI) and cardiovascular mortality. However, the association between TyG-ABSI and incident stroke has not been explored. Our study utilized a prospective cohort design to explore the potential association between TyG-ABSI and incident stroke within a Chinese population.
methodsA total of 8,715 subjects from the China Health and Retirement Longitudinal Study were included in this analysis, categorized into stroke (n = 805) and non-stroke (n = 7,910) groups. To assess the association between TyG-ABSI and incident stroke, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroup analyses, and sensitivity analyses.
resultsThe mean age of participants was significantly higher in the stroke group (61.26 ± 8.42 years) compared to the non-stroke group (59.14 ± 9.27 years). Multivariate analysis revealed that higher TyG-ABSI was significantly associated with increased stroke risk, with an HR of 1.22 (95% CI: 1.09-1.37, P = 0.0004). Notably, this association between TyG-ABSI and incident stroke was non-linear, and a significant inflection point was identified at a TyG-ABSI of 6.42. The HR to the left and right of this inflection point were 2.44 (95%CI: 1.19-5.02, P = 0.0151) and 1.16 (95%CI: 1.02-1.31, P = 0.0239), respectively. Subgroup and sensitivity analyses further validated the robustness of the association between TyG-ABSI and incident stroke.
conclusionOur analysis revealed a non-linear positive association between TyG-ABSI and incident stroke. These findings emphasize the necessity of incorporating TyG-ABSI monitoring into clinical practice to identify individuals at greater risk for stroke.
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