GLP-1 receptor agonists × cardiovascular events

SynthesisEuropean journal of medical research2025

Semaglutide reduces cardiovascular events in type 2 diabetes: a systematic review and meta-analysis highlighting enhanced benefits in chronic kidney disease.

Yanni Yao et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 632 people · 2025

Randomised comparison

Probably reduced deaths

−23%−32% to −12%

Bigger than 7 in 10 for all-cause mortality

As reported

HR 0.77, 95% CI 0.68–0.88 · the paper's word: All-cause mortality

Randomised comparison

Probably reduced cardiovascular events

−32%−44% to −17%

Bigger than 7 in 10 for cardiovascular events

As reported

HR 0.68, 95% CI 0.56–0.83

Randomised comparison

Probably reduced cardiovascular events

−18%−32% to −8%

Bigger than 4 in 10 for cardiovascular events

As reported

HR 0.82, 95% CI 0.68–0.92

Randomised comparison

Probably reduced cardiovascular events

−18%−25% to −10%

Bigger than 4 in 10 for cardiovascular events

As reported

HR 0.82, 95% CI 0.75–0.90

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

of cardiovascular (CV) death by 23% [HR 0.77, 95% CI (0.68, 0.88)], major adverse cardiovascular events (MACE) by 18% [HR 0.82, 95% CI (0.75, 0.90)], expanded MACE by 22% [HR 0.78, 95% CI (0.70, 0.85)], nonfatal myocardial infarction (MI) by 18% [HR 0.82, 95% CI (0.68, 0.92)], and

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 0.770.68–0.88
Cardiovascular events
HR 0.680.56–0.83
Cardiovascular events
HR 0.820.68–0.92
Cardiovascular events
HR 0.820.75–0.90
Cardiovascular events
HR 0.780.70–0.85
GLP-1 receptor agonistsCardiovascular eventsAll-cause mortality

GLP-1 receptor agonists × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted

GLP-1 receptor agonists × all-cause mortalityhelps?replicated

unlikelylikely
0.88not counted
← favours treatmentfavours comparator →
more certainless certain
1 / 5

2 papers cite it

2025
2026
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 41188987