ArticleFrontiers in human neuroscience2025
Enlarged perivascular spaces in the basal ganglia mediate the negative impact of HbA1c levels on mild cognitive impairment.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Investigation of type 2 diabetes mellitus and mild cognitive impairment: a study based on diffusion tensor imaging analysis along the perivascular space and peak width of skeletonized mean diffusivity.Quantitative imaging in medicine and surgery · 2026Article
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8 authors.
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Abstract
Background: This study aimed to investigate the mediating effect of enlarged perivascular space (EPVS) in basal ganglia (BG) on the relationship between glycated hemoglobin (HbA1c) levels and mild cognitive impairment (MCI) in patients with cerebral small vessel disease (CSVD). Methods: Data on HbA1c levels and MOCA scores and CSVD imaging markers, including EPVS volume and distribution patterns were collected. Logistic regression was performed to identify independent risk factors for MCI. A mediation effect analysis was further conducted to determine whether BG-EPVS mediate the impact of HbA1c on cognitive impairment. Results: A total of 244 CSVD patients were enrolled in this study. Compared with non-DM patients, DM patients had a significantly greater BG-EPVS volume ( Conclusion: HbA1c is an independent risk factor for MCI. Increased BG-EPVS volume mediates the partial effect of HbA1c on CSVD-related cognitive dysfunction.
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