ArticleCureus2025
Defining the Stem Cell Niche in Developing Pericoronal Dental Follicles.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Prolonged high-density culture with restricted medium renewal induces epithelial-like plasticity in apical papilla stem cells.Biomolecules & biomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe pericoronal dental follicle is a connective tissue structure encased in epithelium present around the developing tooth germ before erupting and emerging in the oral cavity. Stem cells from pericoronal follicles can be obtained and cultured under suitable conditions in vitro. This study builds upon our previous research, with the primary objective of identifying stem cell subpopulations in the oral cavity based on marker expression and differentiation potential. MATERIALS AND
methodsDental follicle stem cells (DFSCs) were obtained and cultured under standard cell culturing conditions. Cellular phenotype and the expression of stem cell and tissue markers were analyzed using high-throughput fluorescent analysis. Additionally, the cells were cultured for 10 days in differentiation media to assess their osteogenic, adipogenic, and chondrogenic differentiation potential in vitro. Stem cell differentiation was evaluated using Alcian Blue, Oil Red O, and Alizarin Red staining.
resultsThe stem cells isolated by the research team showed positive fluorescent expression for epithelial markers and mesenchymal markers (CD44H, CD71, CD90). High-content cellular analysis enabled the quantitative profiling of DFSC marker expression. Under appropriate conditions, DFSCs demonstrated the ability to differentiate into osteoblast-like, chondroblast-like, and adipocyte-like cells in vitro.
conclusionThe dental follicle contains a population of stem cells with a specific phenotype capable of multilineage differentiation. It may represent another promising source of human adult stem cells. The observed differentiation profile may limit the application of the isolated cells in the hard tissue regeneration and suggest a potentially more suitable role in soft tissue engineering or immunomodulatory therapies.
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Registered trials
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