Evidence map›Paper›PMID 41190069›Full record

ArticleFrontiers in immunology2025

The power of GM-CSF: immune regulation in the defense against

Qi Dong, Jiejie Lu, Mengying Liu, Weiwei Wu, Yuying Kang, Ruijun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi Dong *Department of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Jiejie Lu *Department of Dermatology, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, China.
Mengying LiuDepartment of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Weiwei WuDepartment of Dermatology, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, China.
Yuying KangDepartment of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Ruijun ZhangDepartment of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: This study aims to investigate the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in host defense against Methods: C57BL/6 wild-type (WT) and GM-CSF-deficient ( Results: Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. Conclusion: This study reveals the indispensable role of GM-CSF in antifungal immunity and its potential as a therapeutic target for controlling infections caused by dematiaceous fungi.

Indexed as

Granulocyte-Macrophage Colony-Stimulating FactorMycosesPhialophoraAnimalsCytokinesDisease Models, AnimalMacrophagesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPhagocytosisCytokinesGranulocyte-Macrophage Colony-Stimulating FactorGM-CSFimmune responsemacrophagesneutrophilsPhialophora verrucosa

Identifiers

PMID41190069
PMCPMC12580205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.