ArticleFrontiers in microbiology2025
Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Preeclampsia (PE), a leading cause of maternal and fetal morbidity, remains poorly understood mechanistically. While metal elements like manganese (Mn) are critical for placental function, their interplay with gut microbiota in PE pathogenesis is underexplored. This study evaluates placental heavy metal exposure-particularly Mn-and its interaction with gut microbiota in modulating PE risk. Methods: The study included 21 healthy pregnant women (Control group), and 21 pregnant women diagnosed with PE (PE group). Placental samples were collected to measure metal elements concentrations, while fecal samples were obtained to assess gut microbiota composition. Associations between gut microbiota, PE, and placental Mn levels were analyzed using the Analysis of Composition of Microbiomes with Bias Correction 2 method. Additionally, KEGG pathway enrichment analysis was conducted to identify metabolic pathways linked to PE and Mn levels. Results: Mn levels were significantly lower in the PE group compared to the Control group ( Conclusion: Our findings suggest that Mn may serve as a protective factor against PE within a certain concentration range. Interactions between Mn and specific bacterial genera (
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