Evidence map›Paper›PMID 41190608›Full record

ArticleJournal of the American Chemical Society2025

Highly Sensitive Detection of Tyrosine and Neurotransmitters by Stereoselective Biosynthesis and Photochemically Induced Dynamic Nuclear Polarization.

Ummay Mahfuza Shapla, Jamorious L Smith, Anubhab Halder, Lillian Thompson, Andrew R Buller, Silvia Cavagnero

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Fluorinated Tryptophan Derivatives for Photo-CIDNP NMR.The journal of physical chemistry. B · 2026
    Article
  2. Nuclear-Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra-High Field.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ummay Mahfuza ShaplaDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.
Jamorious L SmithDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.
Anubhab HalderDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.
Lillian ThompsonDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.
Andrew R BullerDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.ORCID 0000-0002-9635-4844
Silvia CavagneroDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, United States.ORCID 0000-0002-4290-2331

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Development of LED-Assisted NMR Technologies for the Atomic-Resolution Analysis of Medically Relevant Biomolecules in Solution at Submicromolar ConcentrationR01GM125995 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2018 to 2025
$2.8M
Engineering in vivo biomolecular synthesis with non-standard building blocksDP2GM137417 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BULLER, ANDREW · 2019 to 2019
$2.2M
Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
Engineering promiscuous enzymes for synthesis of biological building blocksR35GM153276 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BULLER, ANDREW · 2024 to 2025
$800k
NIGMS NIH HHS DP2 GM137417NIGMS NIH HHS R01 GM125995NIGMS NIH HHS R35 GM153276NIGMS NIH HHS T32 GM008505NIH HHS S10 OD012245
6 · The paper itself

Abstract

Tyrosine (Tyr) is a building block of proteins and a precursor of key neurotransmitters including dopamine and epinephrine. Investigations on the metabolic fate of Tyr are hampered by poor sensitivity and resolution, hindering the diagnosis of debilitating diseases including phenylketonuria, tyrosine-hydroxylase deficiency and progressive infantile encephalopathy. Here, we show that Tyr constructs bearing either a quasi-isolated

Indexed as

Neurotransmitter AgentsTyrosineHumansMagnetic Resonance SpectroscopyPhotochemical ProcessesStereoisomerismNeurotransmitter AgentsTyrosine

Identifiers

PMID41190608
PMCPMC12636019

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.