ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Interior Decorative VOCs Elevate T Cell-Mediated Obstructive Lung Disease Risks via Osteogenesis-Driven Lymphoid-Biased Hematopoiesis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Indoor VOCs Exposure Disrupts Hemostatic Balance: Plasma Proteomics Identifies Complement and Coagulation Cascade Dysregulation as a Critical Signature.Environment & health (Washington, D.C.) · 2026Article
- Interior Decorative VOCs Elevate T Cell-Mediated Obstructive Lung Disease Risks via Osteogenesis-Driven Lymphoid-Biased Hematopoiesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Volatile organic compounds (VOCs) emitted from interior decorations are suggested to pose substantial respiratory hazards as they disturb the immune response in the lung. Despite this, the characteristics and mechanisms underlying immune cell responses to real-world VOC mixtures, rather than previously individual or dominant VOC species, remain poorly understood. Employing a whole-body inhalation exposure model, we reveal that interior decorative VOCs alter pulmonary immune cell profiles with a persistent increase in alveolar T cells. This sustained elevation results from intensified lymphoid-biased hematopoiesis in the bone marrow (BM) rather than in situ lung, which is followed by thymic maturation and subsequent recruitment to lung tissues. The ex vivo biosensor and antibody neutralization assays clarify that VOCs-induced lymphoid-biased hematopoiesis is primarily driven by osteogenic differentiation within the BM niche, a process further regulated by interleukin-6 (IL-6) and interleukin-17A (IL-17A). Moreover, the cohort study associates VOCs-expanded lymphocytes with increased risks of obstructive lung diseases, where exposed individuals show elevated IL-6 and IL-17A levels, correlating with VOC concentrations and lymphocyte proportions. These findings highlight compelling indicators (i.e., T cells) and potential interventions (i.e., IL-6 and IL-17A) for evaluating and mitigating VOC-associated respiratory risks.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.