Evidence map›Paper›PMID 41191120›Full record

ReviewArchives of microbiology2025

Microbial membrane vesicles and the intestinal epithelium: a crosstalk in health and disease.

Abdulwasid Abubakari, Kafilat T Salvador-Oke, Halimatu S M-Kamal, Awopetu Mobolaji Johnson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abdulwasid AbubakariDepartment of Science Laboratory Technology, Accra Technical University, Accra, Ghana. abdulwasid25121993@gmail.com.
Kafilat T Salvador-OkeDivision of Medical Microbiology and Immunology, Stellenbosch University, Stellenbosch, South Africa.
Halimatu S M-KamalDepartment of Physician Assistantship, Garden City University, Kumasi, Ghana.
Awopetu Mobolaji JohnsonDepartment of Industrial biotechnology, Osun State University, Osogbo, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal epithelium maintains a critical dialogue with the gut microbiota. A key mechanism in this communication is the release of bacterial membrane vesicles (MVs), which act as functional carriers of bioactive cargo. This review explores the central role of MVs in mediating the crosstalk between the gut microbiota and the intestinal epithelium. We summarize the biogenesis of Gram-negative outer membrane vesicles (OMVs) and Gram-positive cytoplasmic membrane vesicles (CMVs) and detail the molecular pathways of their interaction with host intestinal epithelial cells, including endocytic uptake and pattern recognition receptor signaling. We then discuss the dual role of this communication: MVs from commensal bacteria are crucial for maintaining intestinal homeostasis by enhancing barrier integrity and modulating immune responses, while MVs from pathogenic bacteria contribute to diseases like inflammatory bowel disease (IBD) and colorectal cancer (CRC) by delivering virulence factors and promoting inflammation. Finally, we critically evaluate the emerging potential of MVs as non-invasive diagnostic biomarkers and as engineered therapeutic platforms for targeted drug delivery and vaccination, while highlighting the significant translational challenges that remain.

Indexed as

Bacterial Outer MembraneGastrointestinal MicrobiomeIntestinal MucosaAnimalsColorectal NeoplasmsExtracellular VesiclesHumansInflammatory Bowel DiseasesCytoplasmic membrane vesiclesDysbiosisGut epitheliumInflammatory bowel diseaseIntestinal epithelial cellsMembrane vesiclesOuter membrane vesiclesPattern recognition receptors

Identifiers

PMID41191120

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.