7-chloro-4-(phenylselanyl) quinoline (4-PSQ) modulates biochemical and behavioral adaptations during the early developmental stage of a post-traumatic stress disorder (PTSD) model in mice.

Carolina C Martins, Angélica S Reis, Ketlyn P da Motta, Vanessa M E da Rocha, Lívia Drawanz Jeske, Diego Alves, Cristiane Luchese, Ethel A Wilhelm

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Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Carolina C MartinsPreclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA - Federal University of Pelotas, UFPel, P.O. Box 354, Pelotas, RS, 96010-900, Brazil.

Angélica S ReisPreclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA - Federal University of Pelotas, UFPel, P.O. Box 354, Pelotas, RS, 96010-900, Brazil.

Ketlyn P da MottaPreclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA - Federal University of Pelotas, UFPel, P.O. Box 354, Pelotas, RS, 96010-900, Brazil.

Vanessa M E da RochaPreclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA - Federal University of Pelotas, UFPel, P.O. Box 354, Pelotas, RS, 96010-900, Brazil.

Lívia Drawanz JeskeGraduate Program in Chemistry, Clean Organic Synthesis Laboratory - LASOL - CCQFA, Federal University of Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.

Diego AlvesGraduate Program in Chemistry, Clean Organic Synthesis Laboratory - LASOL - CCQFA, Federal University of Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.

Cristiane LucheseGraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Campus Capão Do Leão, Pelotas, RS, CEP 96010-900, Brazil.

Ethel A WilhelmPreclinical and Translational Research Group on Pain and Chronic Diseases, CCQFA - Federal University of Pelotas, UFPel, P.O. Box 354, Pelotas, RS, 96010-900, Brazil. ethel.wilhelm@ufpel.edu.br.ORCID 0000-0002-2875-9962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroprotective effects of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) have been reported in experimental models of central nervous system (CNS) disorders due to its multi-target actions. Considering the limited efficacy of current treatments for post-traumatic stress disorder (PTSD), this study aimed to investigate the anti-PTSD-like effects of 4-PSQ and its underlying mechanisms during the early developmental stage of single prolonged stress (SPS)-induced PTSD in male and female mice. Following 4 h to the SPS exposure, mice were treated with 4-PSQ (5 mg kg

Indexed as

Behavior, AnimalNeuroprotective AgentsQuinolinesStress Disorders, Post-TraumaticAnimalsAnxietyBrainDisease Models, AnimalFearFemaleMaleMaze LearningMiceNeuroprotective AgentsQuinolinesAChEK+-ATPaseNa+Oxidative stressPTSDSeleniumSex

Identifiers

PMID41191160

DOI10.1007/s11011-025-01674-y

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.