Genetic Loci of TNFα Level Regulation in Blood Serum of Women with Uterine Fibroids.

V I Konenkov, V F Prokofiev, A V Shevchenko, E G Koroleva

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

V I KonenkovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. vikonenkov@gmail.ru.

V F ProkofievResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

A V ShevchenkoResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

E G KorolevaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TNFα content in the blood serum of 109 patients with uterine fibroids was studied. Cytokine concentrations ranged from 4.65 to 25.88 pg/ml regardless of the clinical parameters of the disease, but were associated with complex genotypes of different structural and functional organization (TNFA, IL1B, IL4, IL6, IL8, IL10, IL17A, VEGFA, MMP2, MMP3, MMP9). The interaction of multiple genes that affect the level of serum TNFα production has been revealed. In particular, on the one hand, the complex genotype TNF-308GG/VEGF-2578CA is positively associated with high levels of TNFα (OR = 10.00, p

Indexed as

LeiomyomaTumor Necrosis Factor-alphaUterine NeoplasmsAdultFemaleGenetic LociGenetic Predisposition to DiseaseGenotypeHumansInterleukin-10Interleukin-6Interleukin-8Matrix Metalloproteinase 2Matrix Metalloproteinase 3Matrix Metalloproteinase 9Middle AgedInterleukin-10Interleukin-6Interleukin-8Matrix Metalloproteinase 2Matrix Metalloproteinase 3Matrix Metalloproteinase 9MMP2 protein, humanMMP3 protein, humanTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVEGFA protein, humancombined genotypesMMP and VEGF genesTNFα genesuterine fibroids

Identifiers

PMID41191236

DOI10.1016/j.fertnstert.2016.10.035

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