ArticleClinical transplantation2025
Five Decades of Pancreas Transplantation at the University Hospital of Zurich-A Story of Continuous Improvement and Success.
Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Five Decades of Pancreas Transplantation at the University Hospital of Zurich-A Story of Continuous Improvement and Success.Clinical transplantation · 2025Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPancreas transplantation (PT) represents the gold standard in patients with type I diabetes mellitus (T1D) and end-stage kidney disease (ESKD). We aimed to describe the evolution of PT at the University Hospital of Zurich from 1973 to 2023, and to analyze differences in patient and graft survival within different eras of surgical technique.
methodsThis study represents a retrospective analysis of all primary PT performed at the University Hospital Zurich between 1973 and 2023. According to differences in surgical technique, we defined five different eras of PT.
resultsOverall, 280 primary PT were performed. Overall survival at 1, 5, and 10 years improved from 73.5%, 51%, 44.9% in Era 3, to 69.7%, 60.6%, 51.5% in Era 4, and 95.8%, 95.4%, 82.1% in Era 5, respectively (p < 0.001). Insulin-free survival after 1, 5, and 10 years was 34.5%, 25.5%, 16.4% in Era 3, 41.5%, 34.1%, 31.7% in Era 4, and reached 85.5%, 78%, 64.5% in Era 5 (p < 0.001), respectively.
conclusionEnhanced surgical techniques and improvements in immunosuppression helped to overcome many obstacles that hampered the early days of PT, evolving PT into a safe and highly efficient procedure. PT represents the treatment of choice for patients with T1D and ESKD.
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