ArticleAmerican journal of hypertension2026
Sex Differences in Blood Pressure and Cardiovascular Disease in the UK Biobank: A Prospective Cohort Study.
Article in American journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Sex differences in blood pressure and hypertension through adulthood.Clinical kidney journal · 2026Article
- Blood pressure and cardiovascular risk in a contemporary cohort of young adults.American journal of hypertension · 2026Article
- Tianjin Health and Chronic Disease Study (THCDS): study design and baseline characteristics of the cohort - cohort profile.BMJ open · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRecent studies show that cardiovascular disease (CVD) risk increases from a lower nadir of systolic blood pressure (SBP) in women than men, and increases thereafter at a greater rate. This has led to a suggestion that sex-based SBP thresholds are required. We investigated sex differences in the associations of SBP and incident atherosclerotic CVD.
methodsThis prospective study included 420,649 UK Biobank participants with no prior history of CVD. Age-adjusted sex-specific risks, relative risks (RRs), and risk differences (RDs) relating SBP to CVD were estimated using Poisson and Cox regression.
resultsOver 13.6 years of follow-up, there were 28,628 CVD events. CVD risks across BP levels showed a "J-shape," and were higher in men than women at all BP levels. The lowest risks were at SBP 100-<105 mmHg (events per 10,000 person-years [95% CI]: 15.6 [11.8-19.4]) and 110-<115 (47.2 [41.4-53.0]) among women and men, respectively. Compared with SBP 100-<110, sex-specific RRs at above 120 were higher in women than men, but RDs were higher in men than women at all levels of SBP. Compared to men at 110-<115 (ie, the men with least risk), risks in women were lower at all levels of SBP below 170.
conclusionsCVD risk is lowest for women at a slightly lower SBP than men and RRs for CVD increase with SBP at a slightly steeper rate in women. However, both risks and RDs in women are never greater than in men. This evidence does not support lower thresholds for diagnosis of hypertension in women.
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Registered trials
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