ArticleExperimental eye research2026
Temperature and cholesterol regulate the association of native bovine lens alpha-crystallin with in vitro reconstituted membranes made of synthetically prepared lipids and cholesterol.
Article in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
α-Crystallin (αABc) association with the lens membrane is accelerated in cataracts, and cholesterol (Chol) in lens membranes is accelerated in healthy aging and decreases with cataracts. This study investigates how temperature and Chol affect the membrane interactions of αABc. We applied the electron spin resonance method to analyze the membrane association of αABc incubated with (Chol)/model of bovine lens-lipid (MBLL) membranes at temperatures of 30, 37, 45, and 52 °C with Chol/MBLL mixing ratios of 0.0, 0.3, and 1.5. The highest percent of membrane exterior surface occupied (HMEO) by αABc to Chol/MBLL membranes at mixing ratios of 0.0 and 0.3 resulted in the tendency: (37 °C) HMEO > (45 °C) HMEO ≈ (52 °C) HMEO > (30 °C) HMEO. Additionally, the binding affinity (K
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