Evidence map›Paper›PMID 41193246›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2025

Structured narrative review on lung cancer screening: current evidence, clinical practice implications and implementation insights from a multidisciplinary task force and patient representatives.

Georgia Hardavella, Kyriaki Tavernaraki, Dimitrios Lioumpas, Efimia Boutsikou, Eleni Karetsi, Elli Keramida, Alexandros Letsos, Konstantinos Livanios, Ιra Michailidou, Stylianos Benakis and 44 more

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Georgia Hardavella6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Kyriaki TavernarakiDepartment of Computed Tomography and Interventional Radiology, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Dimitrios LioumpasDepartment of Thoracic Surgery, General Hospital of Nikaia, Piraeus, Greece.
Efimia BoutsikouDepartment of Respiratory Medicine and Oncology, "Theageneio" Anti-Cancer Hospital of Thessaloniki, Thessaloniki, Greece.
Eleni KaretsiDepartment of Respiratory Medicine, University General Hospital of Larisa, Mezourlo, Greece.
Elli Keramida6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.ORCID https://orcid.org/0000-0002-0611-2025
Alexandros LetsosDepartment of Radiology, "Evaggelismos" General Hospital of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-3273-8416
Konstantinos LivaniosPrivate Clinic, Respiratory Primary Care, Pirgos, Greece.
Ιra MichailidouDepartment of Respiratory Medicine, "Agios Savvas" Anti-Cancer Hospital of Athens, Athens, Greece.
Stylianos BenakisDepartment of Radiology, "Evaggelismos" General Hospital of Athens, Athens, Greece.ORCID https://orcid.org/0009-0009-4550-6172
Aggeliki PandiDepartment of Respiratory Medicine, "Agia Eirini" District General Hospital of Corfu Island, Kontokali, Greece.
Leonidas PapastavrouDepartment of Thoracic Surgery, Athens' Medical Center, Athens, Greece.
Konstantinos StefanidisDepartment of Radiology, "Metaxa" Anti-Cancer Hospital of Piraeus, Piraeus, Greece.
Eleftherios Zervas7th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.ORCID https://orcid.org/0000-0001-7436-4550
Theoni Agapitou7th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Martha AndritsouDepartment of Respiratory Medicine, "Evaggelismos" General Hospital of Athens, Piraeus, Greece.
Stavros AnevlavisDepartment of Respiratory Medicine, University General Hospital of Alexandroupoli, Alexandroupoli, Greece.
Gerasimos ApollonatosPrivate Clinic, Respiratory Primary Care, Peristeri, Greece.
Kathi ApostolidouHellenic Cancer Federation, Athens, Greece.
Katerina Bakiri1st University Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Zafeiria BarmparessouDepartment of Respiratory Medicine, "Evaggelismos" General Hospital of Athens, Piraeus, Greece.
Elena Bellou6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Danai BisirtzoglouDepartment of Respiratory Medicine, "Agios Savvas" Anti-Cancer Hospital of Athens, Athens, Greece.
Loukas DagdilelisDepartment of Radiology, "G. Papanikolaou" General Hospital of Thessaloniki, Hortiatis, Greece.
Eleni FiliMedical Library, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.ORCID https://orcid.org/0009-0009-2036-2598
Christophoros ForoulisDepartment of Cardiothoracic Surgery, AHEPA University Hospital, Thessaloniki, Greece.
Stylianos GaitanakisDepartment of Thoracic Surgery, 401 Hellenic Army Hospital, Athens, Greece.
Christina Gkriniouk6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
George KapetanakisHellenic Cancer Federation, Athens, Greece.
Konstantinos KaragiannisDepartment of Respiratory Medicine, University General Hospital of Heraklion, Heraklion, Greece.
Ioannis KarampinisDepartment of Thoracic Surgery, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Eleni KokkotouOncology Unit, 3rd Department of Internal Medicine, Athens' School of Medicine, NKUA, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.ORCID https://orcid.org/0009-0000-8067-3042
Alexandra Kote6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Athanasios KostoulasPrivate Clinic, Respiratory Primary Care, Ioannina, Greece.
Sofia LambakiDepartment of Respiratory Medicine, "G. Papanikolaou" General Hospital of Thessaloniki, Thessaloniki, Greece.
Dimitrios MagouliotisDepartment of Thoracic Surgery, University Hospital of Larisa, Mezourlo, Greece.
Maria ManiOncology Unit, 3rd Department of Internal Medicine, Athens' School of Medicine, NKUA, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Gerasimos MetaxasNational Cancer Registry, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Aggeliki MiziouDepartment of Respiratory Medicine, University General Hospital of Larisa, Mezourlo, Greece.
Katerina MproupiNational Cancer Registry, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Styliani MytilinaiouPrivate Clinic, Respiratory Primary Care, Elefsina, Greece.
Konstantinos PotarisDepartment of Thoracic Surgery, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Konstantinos Samitas7th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Vasilios SkourasDepartment of Respiratory Medicine, 401 Hellenic Army Hospital, Athens, Greece.
Dionysis SpyratosDepartment of Respiratory Medicine, "G. Papanikolaou" General Hospital of Thessaloniki, Thessaloniki, Greece.
Andreas StathoulopoulosDepartment of Thoracic Surgery, General Hospital of Nikaia, Piraeus, Greece.
Myrsini StasinopoulouDepartment of Radiology, "Agios Savvas" Anti-Cancer Hospital of Athens, Athens, Greece.
Lamprini StournaraOncology Unit, 3rd Department of Internal Medicine, Athens' School of Medicine, NKUA, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Emmanouil TheodorakisDepartment of Thoracic Surgery, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.
Sokratis TsagaropoulosDepartment of Cardiothoracic Surgery, AHEPA University Hospital, Thessaloniki, Greece.
Stylianos VittorakisPrivate Clinic, Respiratory Primary Care, Chania, Greece.
Charalampos ZisisDepartment of Thoracic Surgery, "Evaggelismos" General Hospital of Athens, Athens, Greece.
Panagiotis ZoisPrivate Clinic, Respiratory Primary Care, Ioannina, Greece.
Ioannis GkiozosOncology Unit, 3rd Department of Internal Medicine, Athens' School of Medicine, NKUA, "Sotiria" Athens' Chest Diseases Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLung cancer screening (LCS) is an evolving field with variations in its implementation worldwide. National LCS programmes are limited and preliminary data from national implementation are scarce.

aimAn up-to-date overview of the available literature about 12 LCS-related topics that were identified as priorities by a multidisciplinary task force (TF) panel and patient representatives as well as synthesis of published evidence to inform clinical practice and health decision-making about LCS implementation. In specific areas where the scientific evidence is limited or mixed, the limitations are discussed and best practices based on available evidence are concluded. MATERIALS AND

methodsA multidisciplinary TF expert panel collaborated with patient representatives, identified 12 areas of interest and incorporated patient priorities. A systematic literature search was conducted, followed by screening, review and synthesis of available evidence.

resultsThere is a lack of national LCS programmes in most countries worldwide. LCS benefits and potential risks are well established. Low-dose computed tomography (LDCT) combined with smoking cessation should be offered as part of a LCS strategy to ensure optimal clinical outcomes. Age and smoking status cut-offs as well as other inclusion criteria vary and should be based on national epidemiological data. Available LCS risk predictor models and biomarkers require further clinical validation prior to implementation across the entire spectrum of LCS candidates. LCS frequency remains controversial with biennial LDCT being supported by current evidence. Technical standards, quality assurance and LCS management protocols are essential in LCS implementation.

conclusionsLCS benefits override potential risks. There is slim evidence for specific cut-off values for inclusion criteria, the optimal duration of LCS programmes and the application of LCS biomarkers in clinical practice. Smoking cessation should be integrated within LCS programmes. Ongoing scientific activity in the area is expected to provide answers in the near future.

Indexed as

Advisory CommitteesEarly Detection of CancerLung NeoplasmsConsensusEvidence-Based MedicineHumansPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSmokingSmoking CessationTomography, X-Ray Computed

Identifiers

PMID41193246
PMCPMC12588082

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.