ArticleBMC infectious diseases2025
Prolonged dysregulation of gene expression and biomarkers of coagulation, fibrinolysis, and endothelium in pediatric central nervous system malaria.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition.BMC medicine · 2026Trial
- Bradykinin contributes to vasogenic edema in murine experimental cerebral malaria.The Journal of clinical investigation · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundChildren with central nervous system malaria (CNS-M) have gene expression profiles and plasma biomarkers of malaria pathogenesis that differ from children with uncomplicated malaria (UM, malaria infection with fever and no systemic organ dysfunction) or acute febrile non-malaria illness (AFN). However, there is scant knowledge of the temporal dynamics of gene expression and plasma biomarkers during recovery from CNS-M.
methodsWe compared serial changes of peripheral blood mononuclear cell transcriptomes at 6 weeks after recovery and plasma biomarkers of malaria pathogenesis at 6 weeks and 6 months after recovery in cohorts of Kenyan children who presented with CNS-M (n = 37), UM (n = 20) and AFN (n = 12).
resultsUpregulated genes and Reactome pathways of interleukin/cytokine signaling, neutrophil degranulation and innate immunity and downregulated pathways of protein biosynthesis of children presenting with CNS-M were partially reversed at hospital discharge 2–6 days later and 6 weeks. CNS-M and UM transcriptomes before treatment versus 6 weeks after recovery shared several pathways, but megakaryocyte/platelet production, IL-4/IL-13/IL-10 signaling and overexpression of LAG3, CCR5, PDGFRB and ICMT were specific to CNS-M. The Hemostasis Reactome pathway was uniquely downregulated in CNS-M at 6 weeks. Biomarkers of coagulation, fibrinolysis, neutrophil activation, endothelium integrity and cytokine signaling correlated with high plasma cell-free DNA in acute CNS-M and persisted for 6 weeks, whereas these values normalized at 6 weeks in UM and AFN.
conclusionsRecovery from pediatric CNS-M is associated with prolonged dysregulation of gene expression and biomarkers associated with coagulation, fibrinolysis and platelet activation. Future studies are needed to evaluate whether this dysregulation is associated with neurocognitive sequelae following recovery. CLINICAL TRIAL: Not applicable.
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