Evidence map›Paper›PMID 41194123›Full record

ReviewStem cell research & therapy2025

Mesenchymal stem cells in sepsis-induced organ dysfunction: mechanisms and therapeutic potential.

Tingyu Yang, Xinqi Xu, Jiapan An, Bin Li, Zhimin Dou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingyu YangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Xinqi XuThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Jiapan AnThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Bin LiThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Zhimin DouThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China. ldyy_douzhimin@lzu.edu.cn.ORCID http://orcid.org/0009-0007-3986-2758

Funding

Gansu Provincial Health Industry Research Program GSWSKY2023-24Gansu Provincial Youth Science and Technology Foundation 20JR10RA710National Natural Science Foundation of China 82160358
6 · The paper itself

Abstract

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a maladaptive host response to infection and remains a leading cause of mortality in critically ill patients. Organ dysfunction frequently occurs as a sepsis complication, exacerbating systemic inflammation and contributing to increased mortality. Current treatment modalities for sepsis-induced organ dysfunction (SIOD) are limited to infection control, organ function support, and anti-inflammatory interventions. However, their effectiveness is limited. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative properties and offer a promising therapeutic approach for addressing SIOD syndrome through diverse mechanisms. This review elucidates the pathophysiological basis of SIOD, investigates the potential mechanisms and therapeutic applications of MSCs in the management of SIOD, and outlines existing challenges to underpin future MSC-based strategies for sepsis-induced organ injury treatment.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationMultiple Organ FailureSepsisAnimalsHumansExosomesMesenchymal stem cellsOrgan dysfunctionSepsis

Identifiers

PMID41194123
PMCPMC12590784

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.