Evidence map›Paper›PMID 41194213›Full record

ArticleHead & face medicine2025

Characteristics of preoperative electrically evoked middle latency responses and postoperative cochlear implant effects in patients with tinnitus.

Bin Wang, Xiaohui Guo, Chaogang Wei, Wei Lv, Zhiqiang Gao, Suju Wang, Keli Cao

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Article in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Bin Wang *Department of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Xiaohui Guo *Senior Department of Ophthalmology, the Third Medical Center of PLA General Hospital, Beijing, 100853, China.
Chaogang WeiDepartment of Otolaryngology-Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.
Wei LvDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Zhiqiang GaoDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Suju WangDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Keli CaoDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. caokeli_ckl@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyse the characteristics of electrically evoked middle latency responses (EMLR) in patients with profound sensorineural hearing loss (SNHL) and tinnitus.

methodsThirty adults with profound SNHL and tinnitus who underwent cochlear implantation were selected as the tinnitus group, and 15 patients with profound SNHL but without tinnitus served as the control group. Preoperative data were retrospectively analysed. Electrically evoked middle latency responses were recorded intraoperatively, and the electrophysiological characteristics were compared between groups. Changes in tinnitus were assessed using the Tinnitus Handicap Inventory (THI), and correlations between EMLR parameters and THI scores were analysed.

resultsNo postoperative complications occurred in any of the patients. Electroauditory responses were successfully elicited in all 45 patients. Intraoperative EMLR showed increased Na-Pa amplitude and delayed Pa latency, with significant differences observed between the tinnitus and control groups (P < 0.05). One year after cochlear implantation, the average comfort level (C value) and the EMLR threshold showed a significant linear correlation (r = 0.915, P < 0.01). Postoperative THI scores showed a significant decrease (P < 0.05) compared with preoperative scores. A significant correlation was found between the intraoperative EMLR Na-Pa wave amplitude and THI change at 1 year (r = 0.815, P < 0.05), with an area under the ROC curve of 0.673 (P = 0.002).

conclusionThe intraoperative EMLR waveform of patients with profound SNHL and tinnitus is significantly different from that of patients without tinnitus. Cochlear stimulation effectively inhibits tinnitus, and EMLR provides an objective tool for evaluating tinnitus and optimising its management. However, further studies with larger sample sizes are needed to validate these preliminary findings.

Indexed as

Cochlear ImplantationCochlear ImplantsHearing Loss, SensorineuralTinnitusAdultAgedFemaleHumansMaleMiddle AgedPostoperative PeriodPreoperative PeriodRetrospective StudiesTreatment OutcomeCochlear implantElectrically evoked middle latency responsesSensorineural hearing lossTinnitusTinnitus handicap inventory

Identifiers

PMID41194213
PMCPMC12587744

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.