Evidence map›Paper›PMID 41194296›Full record

ArticleEuropean journal of medical research2025

CACNB4 attenuates cardiac dysfunction by regulating calcium and ATP levels via interaction with RyR2.

Shan Jiang, Ming Hong, Jingbo Zhang, Fei Xu, Xingqian Zhang, Guanghao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shan JiangDepartment of Emergency, The Second Qilu Hospital of Shandong University, Jinan, China.
Ming HongDepartment of Cardiology, The Second Qilu Hospital of Shandong University, Jinan, China.
Jingbo ZhangDepartment of Cardiology, The Second Qilu Hospital of Shandong University, Jinan, China.
Fei XuDepartment of Cardiology, The Second Qilu Hospital of Shandong University, Jinan, China.
Xingqian ZhangDepartment of Cardiology, The Second Qilu Hospital of Shandong University, Jinan, China.
Guanghao ZhangDepartment of Cardiology, The Second Qilu Hospital of Shandong University, Jinan, China. zhangguanghao@email.sdu.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2020QH009
6 · The paper itself

Abstract

CACNB4 is suspected to be involved in cardiac contraction, its specific role and the underlying mechanisms are not elucidated. We analyzed gene expression profiles of peripheral blood mononuclear cells (PBMCs) from heart failure patients using the GSE235757 data set from the NCBI GEO database. KEGG enrichment analysis was performed to identify pathways associated with differentially expressed genes. Analysis of the GSE235757 data set revealed a significant downregulation of CACNB4 expression in PBMCs of heart failure patients, particularly in the "Cardiac muscle contraction" pathway. Western blot analysis confirmed a reduction in CACNB4 expression in hypoxic myocardial cells and heart tissue from heart failure mice. Overexpression of CACNB4 improved cardiac function, reduced infarct size, alleviated myocardial damage, via enhancing ATP and Ca

Indexed as

Adenosine TriphosphateCalciumCalcium-Binding ProteinsHeart FailureRyanodine Receptor Calcium Release ChannelAnimalsHumansMaleMiceMyocytes, CardiacAdenosine TriphosphateCalciumCalcium-Binding ProteinsRyanodine Receptor Calcium Release ChannelRyR2 protein, humanCa2+CACNB4Cardiac dysfunctionMyocardial contractionRyR2

Identifiers

PMID41194296
PMCPMC12590635

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.