ReviewBrain and behavior2025
The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review.
Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of psychological interventions versus standard care for cancer pain: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine.Brain and behavior · 2026Review
- Effects of Adding MedX Lumbar Extension or Deadlift Exercises to a Core Stabilization Program on Extensor Strength, Disability, and Pain in Men with Chronic Low Back Pain: A Randomized Pilot Trial.Healthcare (Basel, Switzerland) · 2026Article
- Differences in Depression and Anxiety, Quality of Life and Quality of Sleep Between Neuropathic and Nociceptive Patients with Chronic Low Back Pain: A Comparative, Multi-Center, Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Factors associated with preoperative health-related quality of life in patients undergoing lumbar spine surgery: a multi-ethnic Asian cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Trihexyphenidyl Ameliorates Depression-like Behaviors in Adult Zebrafish Exposed to Chronic Unpredictable Stress, Consistent with Regulation of the MAPK Signaling Pathway.Biomolecules · 2026Article
- Frailty and Incident Low Back Pain in Middle-Aged and Older Adults: Longitudinal Evidence and Genetic Triangulation.Journal of pain research · 2026Article
- Non-invasive brain stimulation for chronic low back pain: current techniques and future perspectives.Frontiers in human neuroscience · 2026Article
- Comprehensive nursing intervention improves psychological outcomes, sleep quality, pain, and coping in patients with comorbid depression and thoracolumbar compression fracture.Frontiers in psychiatry · 2026Article
- The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review.Brain and behavior · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purpose of reviewThe primary objective of this review is to explore and elucidate the potential relationship between low back pain (LBP) and depression. As both conditions are prevalent health issues affecting a significant portion of the population, understanding their interplay is crucial for developing effective treatment strategies. By examining the existing research, this review aims to provide insights into the biological, psychological, and social factors that contribute to this intricate relationship. RECENT
findingsRecent research has shown an interdependent relationship between LBP and depression. Chronic pain can lead to depression by affecting daily life and work, whereas depression can exacerbate pain perception due to alterations in brain processing. Studies have shown that pain and emotional regulation share the same brain regions, providing a neurobiological basis for their coexistence. Furthermore, psychological factors such as anxiety, stress, and poor coping mechanisms have been shown to have associations with both conditions. SUMMARY: The relationship between LBP and depression is complex and multifaceted. Addressing both the physical and psychological aspects of these conditions is essential for effective management. Interdisciplinary approaches, including pharmacological treatment, psychological therapy, physical therapy, and lifestyle modifications, should be considered to improve outcomes for patients suffering from both LBP and depression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.