Evidence map›Paper›PMID 41194668›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025

Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue.

Cassia Labeb, Laventa M Obare, Quanhu Sheng, Xiuqi Zhang, Rama Gangula, Kisyua Nthenge, Samuel S Bailin, Mona Mashayekhi, Victoria R Stephens, Lindsey Stolze and 12 more

Abstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The indirect effects of cytomegalovirus infection-mechanisms and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  2. Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Cassia LabebDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Laventa M ObareDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Quanhu ShengDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Xiuqi ZhangDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Rama GangulaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kisyua NthengeDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Samuel S BailinDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Mona MashayekhiDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Victoria R StephensDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Lindsey StolzeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Stephen PriestDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jordan C MaloneDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jared M OakesDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Curtis L GabrielDivision of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Elizabeth J PhillipsDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Spyros A KalamsDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Simon A MallalDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sara GianellaDivision of Infectious Diseases, University of California, San Diego, CA, USA.
John R KoetheDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yan Ru SuDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Tarek AbsiDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Celestine N WanjallaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-9159-5414

Funding

Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Carolyn Audet · 2015 to 2026
$27.5M
Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIVK23HL156759 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WANJALLA, CELESTINE N · 2021 to 2025
$860k
The Gut-Liver Axis in HIV-Related Non-Alcoholic Fatty Liver DiseaseK23DK135420 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Curtis Lee Gabriel · 2023 to 2026
$735k
Burroughs Wellcome Fund 1021480Doris Duke Charitable Foundation 2021193National Heart, Lung and Blood Institute K23HL156759-01A1National Institute of Allergy and Infectious DiseasesNCATS NIH HHSNHLBI NIH HHS K23 HL156759NIAID NIH HHS P30 AI110527NIDDK NIH HHS K23 DK135420
6 · The paper itself

Abstract

Cytomegalovirus (CMV) establishes lifelong latency and is linked to immunosenescence in older and immunocompromised individuals. We hypothesize that CMV drives systemic and tissue-specific immune changes that may contribute to cardiovascular disease (CVD). Thoracic aorta, blood and perivascular mediastinal adipose tissue from cardiac surgery patients (

Indexed as

Adipose TissueCytomegalovirusCytomegalovirus InfectionsAgedAged, 80 and overCD8-Positive T-LymphocytesFemaleHumansMaleMediastinumMiddle Agedadipose tissueageingaortacytomegalovirusT cellsTEMRA

Identifiers

PMID41194668
PMCPMC12590170

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.