ArticleCureus2025
Host Modulation in Periodontology: Redefining Therapy Beyond Scaling and Root Planing.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- LPS-Induced TNF-α and IL-1 Signaling in Periodontitis: Molecular Mechanisms and Therapeutic Opportunities.Current issues in molecular biology · 2026Review
- The Role of the Oral Microbiome in Modulating Therapeutic Outcomes in Lung Cancer: Key Commensals and Clinical Implications.Cancers · 2026Review
- Next-Generation S3-Level Clinical Practice Guidelines in Periodontology: Methodology, Current Evidence, and Future Directions.Dentistry journal · 2026Review
- Efficacy of omega-3 fatty acids supplementation as an adjunct to nonsurgical periodontal therapy in periodontitis: a systematic review and meta-analysis of randomized controlled trials.Revista cientifica odontologica (Universidad Cientifica del Sur)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of periodontal diseases has traditionally centered on mechanical debridement through scaling and root planing, a cornerstone of periodontal therapy. While effective in reducing bacterial load and disrupting biofilm, this approach alone does not fully address the complex host-mediated inflammatory pathways that drive disease progression and tissue destruction. Advances in molecular biology and immunology have revealed the critical role of host response modulation in periodontal pathogenesis, leading to the development of adjunctive therapeutic strategies that go beyond mechanical intervention. Emerging agents, such as subantimicrobial dose doxycycline, non-steroidal anti-inflammatory drugs, pro-resolving lipid mediators, and host-targeted biologics, demonstrate potential in attenuating destructive inflammation while promoting resolution and regeneration. This editorial explores the evolving concept of host modulation in periodontology, emphasizing its role in redefining therapeutic goals, improving long-term outcomes, and personalizing care for patients with periodontitis. By integrating host-modulatory approaches into routine practice, periodontology is poised to transition from a solely pathogen-centered model to a comprehensive, host-focused paradigm.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.