Evidence map›Paper›PMID 41194875›Full record

ArticleFrontiers in pharmacology2025

NeuproGemp, a polyphenol-rich botanical formula, ameliorates Alzheimer's-like pathology in APP/PS1 mice via inhibition of human glutaminyl cyclase.

Tien-Sheng Tseng, Chia-Ching Liaw, Young-Ji Shiao, Ya-I Huang, Yu-Hsiu Cheng, Wang-Chuan Chen, Keng-Chang Tsai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tien-Sheng TsengInstitute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
Chia-Ching LiawNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
Young-Ji ShiaoNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
Ya-I HuangDepartment of Research and Development, Likang Biotechnical Co., Ltd., Tainan, Taiwan.
Yu-Hsiu ChengDepartment of Research and Development, Likang Biotechnical Co., Ltd., Tainan, Taiwan.
Wang-Chuan ChenThe School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
Keng-Chang TsaiNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and amyloid-β (Aβ) accumulation. Increasing evidence suggests that dietary bioactive compounds may modulate neurodegenerative processes. Here, we evaluated the neuroprotective potential of NeuproGemp, a traditional Chinese functional food formula composed of

Indexed as

Alzheimer’s diseaseamyloid-betaglutaminyl cyclasepentagalloylglucosetraditional Chinese medicinezinc-dependent inhibition

Identifiers

PMID41194875
PMCPMC12582971

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.