ArticleFrontiers in neuroanatomy2025
Vascular degeneration and retinal remodeling in rd10 mice: correlating OCT, OCTA, and histological findings.
Article in Frontiers in neuroanatomy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Introduction: Identifying long-term changes in retinal structure and vasculature is essential for interpreting Methods: Transversal retinal sections and wholemount retinas from C57BL/6J and rd10 mice, aged P20 to 24 months, were immunostained to evaluate retinal structure, glial cells, retinal pigment epithelium (RPE), and the vascular network. OCT and OCTA images from the central retina were also analyzed. Results: Significant retinal remodeling in the inner retina occurs over time and was detectable from 4 months using IHC and from 6 months using OCT. Remodeling was characterized by glial activation (reactive gliosis) and the formation of hyperreflective columns, which contain Müller cells, activated microglia, RPE, and choroidal vessels in the late stages. No significant differences were observed between OCTA and IHC vascular density of the superficial vascular plexus (SVP) and deep capillary plexus (DCP) in rd10 mice at any time points, except at 2 months (SVP, Conclusion: Overall, OCTA and IHC yielded comparable long-term vascular density results, supporting OCTA as a reliable, non-invasive tool for studying vessel degeneration in animal models. Therefore, longitudinal
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