ArticleJOR spine2025
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis.
Article in JOR spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Exosome-mediated cholesterol flow drives scoliosis progression via promoting the spinal cartilage-bone positive feedback.Communications biology · 2026Article
- From mechanotransduction to manual therapy: advances in piezo/TRP channels and lumbar degeneration.Frontiers in physiology · 2026Review
- PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis.JOR spine · 2025Article
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Authors and funding
13 authors.
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Abstract
Background: Adolescent idiopathic scoliosis (AIS) is linked to mechanical stress-induced growth plate dysfunction. PIEZO1 (mechanosensitive ion channel) mediates chondrocyte apoptosis via calcium, and primary cilia (mechanosensory organelles) regulate cartilage matrix synthesis, but their interplay in stress-induced growth plate degeneration/ossification remains unclear; this study explored the PIEZO1-primary cilia axis's role. Methods: Conditional IFT88 knockout (IFT88-cKO) mice were generated via Results: PIEZO1 co-localized with primary cilia (ac-α-Tubulin labeled) in chondrocytes; chloral hydrate reduced cil-ia-positive cells (97.2% → 16.6%, Conclusion: The PIEZO1-primary cilia axis mediates stress-induced growth plate degeneration/ossification: stress upregulates PIEZO1, which relies on primary cilia to promote chondrocyte apoptosis and abnormal ossification; cilia disruption alleviates these effects. This provides insights into AIS pathogenesis and identifies PIEZO1/primary cilia as therapeutic targets.
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