Evidence mapPaperPMID 41195338Full record

ReviewFrontiers in cell and developmental biology2025

Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications.

Marketa Hlavackova, Daniel Benak, Kristyna Holzerova, Petra Alanova, Jaroslav Hrdlicka, Miloslava Chalupova, Barbora Opletalova, Bohuslav Ostadal, Frantisek Kolar

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marketa Hlavackova *Laboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Daniel Benak *Laboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Kristyna HolzerovaLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Petra AlanovaLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Jaroslav HrdlickaLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Miloslava ChalupovaLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Barbora OpletalovaLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Bohuslav OstadalLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Frantisek KolarLaboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and progressive β-cell dysfunction. Traditional biomarkers, such as fasting glucose and glycated hemoglobin (HbA1c), offer diagnostic and prognostic value but have limitations in sensitivity and predictive power for disease progression. Recent advances in molecular biology have identified epitranscriptomic modifications as potential biomarkers for T2DM, offering a novel layer of gene expression regulation through reversible RNA modifications. Dysregulation of these modifications has been implicated in insulin resistance, β-cell failure, and diabetes-related complications. Notably, altered levels of N

Indexed as

biomarkersdiabetesepitranscriptomicsm6ApseudouridineRNA modification

Identifiers

PMID41195338
PMCPMC12583049

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.