Evidence map›Paper›PMID 41195641›Full record

Observational studyHuman vaccines & immunotherapeutics2025

Determinants of non-compliance with additional booster doses of the SARS-CoV-2 vaccine in people living with HIV (PWH): An observational study based on a behavioral and epidemiological survey in Rome (Italy).

Giulia Del Duca, Isabella Sperduti, Alessandro Cozzi Lepri, Valentina Mazzotta, Francis Drobniewski, Roberta Gagliardini, Marisa Fusto, Maria Maddalena Plazzi, Jessica Paulicelli, Alessandra Vergori and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giulia Del DucaClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.ORCID 0009-0004-3408-3817
Isabella SperdutiBiostatistics and Bioinformatics Unit-Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Alessandro Cozzi LepriCentre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
Valentina MazzottaClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Francis DrobniewskiDepartment of Infectious Disease, Imperial College, London, UK.
Roberta GagliardiniClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marisa FustoClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Maria Maddalena PlazziClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Jessica PaulicelliClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Alessandra VergoriClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Chiara De PontePharmacy Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paolo FaccendiniPharmacy Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Paola GallìDepartment of Health Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Enrico GirardiDepartment of Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Andrea AntinoriClinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rejection of new anti-SARS-CoV-2 booster doses among immunosuppressed and elderly individuals may be a concern, especially as the intention to vaccinate does not always translate into actual behavior. Few studies have addressed this issue in people living with HIV (PWH). We investigated attitudes of PWH toward SARS-CoV-2 vaccination, focusing on factors associated with noncompliance with additional vaccine doses (AVDs, 4th and 5th). We analyzed participants of the prospective observational HIV-VAC study conducted at the National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome (September 2022-June 2023). Eligible patients with complete vaccination schedules were voluntarily recruited and completed a 13-item survey on demographics and vaccination attitudes. Multivariate logistic regression was used to describe the relationship between "compliant" vs. "non-compliant" groups. Of 316 participants, 240 (75.9%) were compliant and 76 (24.1%) non-compliant. Compliance was 70% for the fourth and 30% for the fifth dose; noncompliance was 19.9% and 4.1%, respectively. Older age (

Indexed as

COVID-19COVID-19 VaccinesHIV InfectionsImmunization, SecondaryPatient ComplianceAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRomeSARS-CoV-2Surveys and QuestionnairesVaccinationCOVID-19 Vaccinesactual behaviorbooster dosesCOVID-19 infectionCOVID-19 vaccinationvaccine acceptancevaccine hesitancy

Identifiers

PMID41195641
PMCPMC12707212

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.