Evidence map›Paper›PMID 41196333›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Preclinical development of [

Achi Haider, Zhiwei Xiao, Jiahui Chen, Stefanie K Pfister, Xin Zhou, Yinlong Li, Ahmad Chaudhary, Chunyu Zhao, Jian Rong, Axel Paehler and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Achi Haider *Department of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Zhiwei Xiao *Department of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Jiahui Chen *Department of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Stefanie K PfisterDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, 30322, Atlanta, GA, USA.
Yinlong LiDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Ahmad ChaudharyDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, 30322, Atlanta, GA, USA.
Chunyu ZhaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Jian RongDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
Axel PaehlerPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Susanne MohrPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Roger D NorcrossPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Michael HonerPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Linjing MuCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Institute of Pharmaceutical Sciences ETH, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Luca GobbiPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Roger SchibliCenter for Radiopharmaceutical Sciences ETH-PSI-USZ, Institute of Pharmaceutical Sciences ETH, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.
Marius C HoenerPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070, Basel, Switzerland.
Steven H LiangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA. steven.liang@emory.edu.

Funding

micro-PET/CT system for preclinical molecular imagingS10OD034326 · OD · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2024 to 2024
$600k
NIH HHS S10 OD034326Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
6 · The paper itself

Abstract

purposeTrace amine-associated receptor 1 (TAAR1) is an emerging therapeutic target with various implications in neuropsychiatric and metabolic disorders. However, the absence of a suitable positron emission tomography (PET) radioligand has precluded non-invasive quantification of TAAR1 expression and drug-receptor interactions in vivo. In this study, we report the preclinical development of [

methods[

resultsTAAR1-2203 exhibited high TAAR1 affinity in competition binding assays across species, with K

conclusion[

Indexed as

Fluorine RadioisotopesGene Expression RegulationPositron-Emission TomographyRadiopharmaceuticalsReceptors, G-Protein-CoupledAnimalsHumansLigandsMaleMiceTissue DistributionFluorine-18Fluorine RadioisotopesLigandsRadiopharmaceuticalsReceptors, G-Protein-Coupled[18F]TAAR1-2203Pancreatic imaging and beta-cell functionPositron emission tomography (PET)Receptor occupancyTrace amine-associated receptor 1 (TAAR1)

Identifiers

PMID41196333
PMCPMC12920416

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.