Evidence mapPaperPMID 41196334Full record

ArticleEuropean journal of applied physiology2026

Skeletal muscle phenotype and blood pressure after acute exercises.

Venla Ylinen, Rasmus I P Valtonen, Ville Stenbäck, Kari A Mäkelä, Juha Näpänkangas, M Juhani Junttila, Risto Kerkelä, Noora Pöllänen, Eija Pirinen, Karl-Heinz Herzig and 1 more

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Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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11 authors.

Venla YlinenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Rasmus I P ValtonenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Ville StenbäckResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Kari A MäkeläResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Juha NäpänkangasDepartment of Pathology, Research Unit of Translational Medicine, University of Oulu, Oulu University Hospital, Oulu, Finland.
M Juhani JunttilaResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Risto KerkeläResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Noora PöllänenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014, Helsinki, Finland.
Eija PirinenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Karl-Heinz HerzigResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Mikko P TulppoResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland. mikko.tulppo@oulu.fi.ORCID http://orcid.org/0000-0001-5598-9109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe inter-individual responses in systolic blood pressure (SBP) vary from no change to marked reduction after acute exercise. We hypothesized that skeletal muscle phenotype modifies SBP responses.

methodsNormotensive participants (12 males and 8 females, age 27 ± 6 years) performed two 30-min exercises, continuous and interval, by cycle ergometer on separate days. The area under the curve (AUC) for SBP was calculated until 60 min after exercise. Intensity of continuous exercise was 60% of peak exercise workload and interval exercise 8 × 1 min intervals (80-90% of peak exercise workload) with 2 min easy cycling between. The average workload was equal for both exercises (60%). Stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR), and baroreflex sensitivity (BRS) were measured at rest and after exercise. Muscle biopsies were taken from vastus lateralis on separate days, and the percentage of slow/fast fibers, capillary density and mitochondrial respiration were analyzed.

resultsAUC for SBP was - 386 ± 387 vs -399 ± 228 mmHg·min (p = 0.89) after continuous and interval exercises, respectively. After interval exercise, AUC correlated with the percentage of fast fibers (r = - 0.60, p = 0.010) and, eg, with ΔCO (r = 0.45, p = 0.049) and ΔBRS (r = 0.48, p = 0.046). In the stepwise linear regression analysis, the percentage of fast fibers was the strongest predictor of AUC after interval exercise (partial correlation r = - 0.53, β = - 5.9, p = 0.024). AUC after continuous exercise did not correlate with any outcomes.

conclusionParticipants with a greater proportion of fast fibers had superior SBP reductions after interval exercise. The muscle phenotype is an independent determinant of postexercise SBP after interval exercise.

Indexed as

Blood PressureExerciseMuscle, SkeletalAdultBaroreflexFemaleHumansMalePhenotypeAerobic exerciseInter-individual responsesMuscle fiber compositionPostexercise hypotension

Identifiers

PMID41196334
PMCPMC13171934

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