Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Mengze Sun *Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-8798-4326
Baiyan Lu *School of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0009-0002-1197-9632
Ying YangSchool of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0009-0002-2192-0271
Junping FanBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-2615-8098
Weiwei RenDevelopment Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China.ORCID 0009-0006-7333-1881
Xiaonan ChuSchool of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0009-0009-4072-5261
Yihui GaoBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0006-2832-8894
Jun WuSchool of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0000-0002-3381-2561
Jue WangBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.
Han KeBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.
Zhiwen LiuSchool of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0000-0002-8794-173X
Shaojun DaiDevelopment Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China.ORCID 0000-0001-8063-6946
Xiaoguang LeiBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-0380-8035
Chao LiSchool of Life Sciences, East China Normal University, Shanghai 200241, China.ORCID 0000-0003-4537-8050
Funding
Beijing Outstanding Young Scientist Program BJJWZYJH012019492 10001001China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) 2024M760929MOST | National Key Research and Development Program of China (NKPs) 2022YFC2502500489MOST | National Key Research and Development Program of China (NKPs) 2022YFC3401500MOST | National Natural Science Foundation of China (NSFC) 22193073MOST | National Natural Science Foundation of China (NSFC) 32230009MOST | National Natural Science Foundation of China (NSFC) 32425008MOST | National Natural Science Foundation of China (NSFC) 92253305Science and Technology Commission of Shanghai Municipality (STCSM) 24N12800100
6 · The paper itself
Abstract
Since its initial identification as the receptor for Rapid Alkalinization Factor 1 (RALF1), FERONIA (FER) receptor kinase has emerged as a central signaling hub coordinating plant development, stress adaptation, and immune responses. Nevertheless, fundamental questions persist regarding the precise mechanisms of FER-mediated signal transduction and its context-dependent functional specialization in multicellular processes. Here, we develop Ferovicin (FRV), a small-molecule inhibitor that specifically disrupts FER kinase activity, thereby enabling mechanistic dissection of FER. Cocrystallization and mutational analysis show that FRV selectively binds to the ATP-binding pocket of the kinase domain of FER and inhibits its kinase activity. Assisted by the FRV tool and quantitative phosphoproteomics, we characterized a series of signaling pathways and networks regulated by RALF1 and FER. Notably, our analysis reveals that RALF1 activates FER through phosphorylation at Ser695, which subsequently inhibits H
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Unveiling FERONIA receptor kinase-mediated cellular mechanisms with a small-molecule inhibitor. · full record | Socratic