ArticleProceedings of the National Academy of Sciences of the United States of America2025
Divergent evolutionary dynamics of benign and malignant tumors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Indirect genomic effects shape cancer risk across species.bioRxiv : the preprint server for biology · 2026Article
- What Is-and What Is Not-Immunogenic Cell Death? Functional Definitions, Experimental Standards, and Common Pitfalls.International journal of molecular sciences · 2026Review
- Reply to Compton et al.: Another paradoxical misunderstanding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Divergent understandings in comparative oncology.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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5 authors.
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Abstract
Benign and malignant (cancerous) tumors differ markedly in their impact on organismal fitness, yet studies in comparative oncology rarely distinguish between them. Using a Bayesian phylogenetic framework across birds and mammals, we show that while both tumor types increase in prevalence with body mass, only the prevalence of malignant tumors is negatively associated with the rate of body size evolution-suggesting that adaptive mechanisms of cancer defense are associated with rapidly evolving lineages. Additionally, the rate of lineage diversification is positively associated with the prevalence of both tumor types in birds but not mammals, potentially reflecting differences in genome architecture and speciation dynamics. Together, these results highlight distinct macroevolutionary drivers of benign versus malignant tumor prevalence and underscore the value of treating tumor types separately in comparative oncology.
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