Evidence map›Paper›PMID 41196372›Full record

ArticleHistochemistry and cell biology2025

Metformin promotes wound healing in senescent fibroblasts by regulating SIRT1 and FAP-α.

Dilan Cetinavci, Volkan Yasar, Gurkan Yigitturk, Hulya Elbe

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dilan CetinavciDepartment of Histology and Embryology, Mugla Training and Research Hospital, Mugla, Turkey. drdilancetinavci@hotmail.com.ORCID http://orcid.org/0000-0002-4148-7711
Volkan YasarFaculty of Medicine, Department of Histology and Embryology, Mugla Sitki Kocman University, Mugla, Turkey.
Gurkan YigitturkFaculty of Medicine, Department of Histology and Embryology, Mugla Sitki Kocman University, Mugla, Turkey.
Hulya ElbeInstitute of Health Sciences, Department of Health of the Elderly, Mugla Sitki Kocman University, Mugla, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin aging is associated with fibroblast senescence, impaired wound healing, and dysregulation of markers such as sirtuin 1 (SIRT1) and fibroblast activation protein-α (FAP-α). It is known that proliferation and migration decrease in aging fibroblasts, which delays the repair process. Metformin, a widely used anti-diabetic drug, can regulate cellular senescence pathways. This study evaluated the effects of metformin on wound healing and SIRT1 and FAP-α expression in senescent fibroblasts. Cellular senescence was induced in primary human dermal fibroblasts using 100 µM hydrogen peroxide (H

Indexed as

Cellular SenescenceFibroblastsGelatinasesMembrane ProteinsMetforminSerine EndopeptidasesSirtuin 1Wound HealingCells, CulturedEndopeptidasesFibroblast Activation Protein AlphaHumansEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsMetforminSerine EndopeptidasesSIRT1 protein, humanSirtuin 1AgingFAP-αFibroblastMetforminSIRT1Wound healing

Identifiers

PMID41196372

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.