Evidence map›Paper›PMID 41196448›Full record

ArticleImmunologic research2025

Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport.

Qifan Huo, Yuming Zhang, Jianwei Guo, Yan-An Jiang, Jing Zhao

Abstract read
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In one paragraph

Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qifan HuoDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Yuming ZhangDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Jianwei GuoDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Yan-An JiangDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Jing ZhaoDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China. zhaojingsx@163.com.

Funding

Natural Science Basic Research Program of Shaanxi Province 2025JC-YBQN-1067Research Incubation Fund of Shaanxi Provincial People's Hospital 2023YJY-01Science and Technology Talent Support Program of Shaanxi Provincial People's Hospital 2023BJ-02, 2023JY-50, 2023JY-34
6 · The paper itself

Abstract

Dexmedetomidine (Dex), an α2 adrenergic receptor agonist, has been shown to exert protective effects against postoperative neurocognitive disorder (PND) following anesthesia and surgery. This study aimed to investigate the underlying mechanisms, with a focus on the inositol 1,4,5-triphosphate receptor (IP3R)-voltage-dependent anion channel 1 (VDAC1)-chaperone glucose-regulated protein 75 (GRP75) calcium transport protein complex-mediated mitochondrial dysfunction. An in vitro sevoflurane-induced SH-SY5Y cell injury model and an in vivo PND rat model induced by sevoflurane anesthesia plus laparotomy were established, and both models were pretreated with Dex. Subsequent assessment included cell viability, apoptosis, inflammatory cytokines, reactive oxygen species (ROS), mitochondrial calcium ion (Ca

Indexed as

DexmedetomidineHSP70 Heat-Shock ProteinsInositol 1,4,5-Trisphosphate ReceptorsMembrane ProteinsMitochondriaNeuroprotective AgentsPostoperative Cognitive ComplicationsVoltage-Dependent Anion Channel 1AnimalsApoptosisCalciumCell Line, TumorDisease Models, AnimalHumansMaleRatsCalciumDexmedetomidineglucose-regulated proteinsHSP70 Heat-Shock ProteinsInositol 1,4,5-Trisphosphate ReceptorsMembrane ProteinsNeuroprotective AgentsReactive Oxygen SpeciesSevofluraneVdac1 protein, ratVoltage-Dependent Anion Channel 1DexmedetomidineIP3R-GRP75-VDAC1 complexMitochondrial calcium homeostasisMitochondrial dysfunctionPostoperative neurocognitive disorderSevoflurane

Identifiers

PMID41196448

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.