Evidence map›Paper›PMID 41196463›Full record

SynthesisAging clinical and experimental research2025

Association of sarcopenic obesity with cognitive dysfunction and dementia: a systematic review and meta-analysis.

Chunbian Tang, Ying Song, Fengran Tao, Jiayi Hao, Li Yan, Xiuxia Shi, Runnan Pei, Baoqi Zeng

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chunbian Tang *Medical School of Tianjin University, Tianjin, China.
Ying Song *Medical School of Tianjin University, Tianjin, China. songying_1975@tju.edu.cn.
Fengran Tao *Office of the President, Peking University Binhai Hospital, Tianjin Fifth Central Hospital), NO.41, Zhejiang Road, Binhai New Area, Tianjin, 300450, China.
Jiayi HaoMedical School of Tianjin University, Tianjin, China.
Li YanDepartment of General Medicine, Peking University Binhai Hospital, Tianjin Fifth Central Hospital), Tianjin, China.
Xiuxia ShiDepartment of General Medicine, Peking University Binhai Hospital, Tianjin Fifth Central Hospital), Tianjin, China.
Runnan PeiDepartment of General Medicine, Peking University Binhai Hospital, Tianjin Fifth Central Hospital), Tianjin, China.
Baoqi ZengEmergency Medicine Research Institute, Tianjin Fifth Central Hospital (Peking University Binhai Hospital), NO.41, Zhejiang Road, Binhai New Area, Tianjin, 300450, China. zengbaoqi@126.com.

Funding

Research Innovation and Translation Fund of Tianjin Fifth Central Hospital No. 2024-WG-01Science and Technology Project of the Binhai New Area Health Committee No. 2023BWKZ001Tianjin Key Medical Discipline Construction Project Grant No. TJYXZDXK-3-003D
6 · The paper itself

Abstract

objectiveCurrently, the association of sarcopenic obesity (SO) with cognitive dysfunction and dementia remains unclear. This study aims to investigate their potential association. MATERIALS AND

methodsPubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were systematically searched until 30 December 2024. Observational studies investigating the association of SO with cognitive dysfunction and dementia were included. A random-effects model was applied for meta-analysis.

resultsSeventeen studies with 274,996 participants were included, of which 11 were included in quantitative analyses. The pooled odds ratio for cognitive dysfunction in patients with SO versus non-SO was 1.71 (95% CI: 1.39-2.11, p < 0.001, I

conclusionsSO appears associated with cognitive dysfunction. However, due to high heterogeneity, very low certainty of evidence, and potential biases, these results should be interpreted cautiously. Future high-quality prospective studies are needed to validate this conclusion. PROSPERO registration number: CRD420251011745.

Indexed as

Cognitive DysfunctionDementiaObesitySarcopeniaAgedFemaleHumansMaleCognitive dysfunctionDementiaMeta-analysisSarcopenic obesitySystematic review

Identifiers

PMID41196463
PMCPMC12592292

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.