Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Zheng Wu *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7355-0316
Phong T Nguyen *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6390-7350
Varun SondhiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-0253-7624
Run-Wen YaoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6183-0273
Zhifang LuDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0003-4446-5259
Tao DaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jui-Chung ChiangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9979-8347
Feng CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5192-9520
Imani M WilliamsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0005-8415-3710
Eliot B BlattChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9515-6547
Zengfu ShangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2396-1416
Ling CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9057-2998
Jing ZhangDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4190-3065
Mya D MooreChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0004-8349-6482
Islam AlshamlehChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiangyi LiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6157-8047
Tamaratare OguChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0001-0654-6296
Lauren G ZachariasChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rainah WinstonChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joao S PatricioChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7045-4532
Xandria JohnsonChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wei-Min ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5247-7826
Qian CongDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8909-0414
Thomas P MathewsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9355-8243
Yuanyuan ZhangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9230-7314
Limei ZhangDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0001-6807-5103
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2705-7432
Funding
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4M
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
University of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Payal Kapur, Payal Kapur · 2016 to 2026
$24.7M
Metabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
UT Southwestern Center for Translational MedicineKL2TR003981 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI ARGENBRIGHT, KEITH EDWARD, TRIVEDI, MADHUKAR H. · 2021 to 2025
$5.9M
Construction of A Lung Cancer Preclinical Model Cross-comparison PlatformR01CA285336 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Ling Cai · 2024 to 2026
$3.1M
Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress ResponseR35GM138157 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZHANG, LIMEI · 2020 to 2024
$2.1M
Translational Cancer Biology (TCB) T32 Training ProgramT32CA291654 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Rolf A Brekken, Jerry William Shay · 2024 to 2026
$1.2M
Harnessing the Power of Data and Artificial Intelligence to Resolve the Human 3D InteractomeR35GM160468 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Qian Cong · 2025 to 2026
$883k
The roles of the UFM1 post-translational modification in cellular metabolismK99GM151439 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI NGUYEN, PHONG THANH · 2023 to 2024
$250k
Functions of Rapidly-Evolving Proteins and Their Roles in PathogenicityK99AI180984 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, JING · 2024 to 2025
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that are incompletely understood. We identified Nudix hydrolase 5 (NUDT5) as a DNPB regulator. During purine salvage, NUDT5 suppresses DNPB independently of its catalytic function but rather through interaction with phosphoribosyl pyrophosphate amidotransferase (PPAT), the rate-limiting enzyme in the DNPB pathway. The NUDT5-PPAT interaction promoted PPAT oligomerization, suppressed PPAT's enzymatic activity, and facilitated disassembly of the purinosome, a metabolon that functions in DNPB. Disrupting the NUDT5-PPAT interaction overcame DNPB suppression during purine salvage, permitting excessive DNPB and inducing thiopurine resistance. Therefore, NUDT5 governs the balance between DNPB and salvage to maintain appropriate cellular purine nucleotide concentrations.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT. · full record | Socratic