Evidence map›Paper›PMID 41197678›Full record

ArticleNeurobiology of disease2025

Thrombospondin-1 regulates synaptic transmission in hippocampal field CA2 and social behavior in mice.

Gerardo Leana-Sandoval, Alexis Madrid, Johanna Extrémet, Ester Aso, Javier Díaz-Alonso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Localization and Functional Characterization of MDGA1 in Mouse Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gerardo Leana-SandovalDepartment of Anatomy & Neurobiology, University of California at Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, CA 92697, USA.
Alexis MadridDepartment of Anatomy & Neurobiology, University of California at Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, CA 92697, USA.
Johanna ExtrémetDepartment of Anatomy & Neurobiology, University of California at Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, CA 92697, USA.
Ester AsoPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Spain.
Javier Díaz-AlonsoDepartment of Anatomy & Neurobiology, University of California at Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, CA 92697, USA. Electronic address: jdiazalo@uci.edu.

Funding

Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
Novel approaches to study AMPA receptor trafficking and LTPR00MH118425 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI DIAZ ALONSO, JAVIER · 2020 to 2022
$745k
Novel approaches to study AMPA receptor trafficking and LTPK99MH118425 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ ALONSO, JAVIER · 2018 to 2019
$242k
National Program for the Promotion of Talent and Employability, Ministry of Universities (Spain)NIMH NIH HHS K99 MH118425NIMH NIH HHS R00 MH118425NINDS NIH HHS T32 NS045540
6 · The paper itself

Abstract

Thrombospondin 1 (TSP1) is a secreted extracellular matrix glycoprotein, which mediates cell-to-cell and cell-to-matrix interactions. In humans, mutations in THBS1, which encodes TSP1, are associated with neurodevelopmental disorders, but the underlying neurobiological mechanisms are unclear. TSP1 is secreted by astrocytes, and has been shown to promote synaptogenesis in vitro, but knowledge about its function in vivo is limited. In this study, we assessed TSP1's modulation of synaptic function and cognitive and emotional processes using TSP1 knockout mice. Deletion of TSP1 led to decreased perineuronal net density and strengthened synaptic transmission in hippocampal field CA2, but not CA1. Accordingly, TSP1 KO mice showed severely disrupted social interaction, as well as emotional alterations, but normal spatial memory. Collectively, our findings identify TSP1 as a crucial modulator of synaptic function in CA2 and social and emotional processes. Furthermore, our work delineates a mechanism linking altered TSP1 signaling with psychiatric conditions with altered social and emotional function.

Indexed as

CA2 Region, HippocampalSocial BehaviorSynaptic TransmissionThrombospondin 1AnimalsMaleMiceMice, Inbred C57BLMice, KnockoutThbs1 protein, mouseThrombospondin 1AMPA receptorAutism spectrum disorderHippocampal field CA2Social behaviorThrombospondin 1

Identifiers

PMID41197678
PMCPMC13308512

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.