Evidence map›Paper›PMID 41198532›Full record

Observational studyOrthopaedic surgery2025

The Outcomes of Patients With Hyperuricemia After Total Knee Arthroplasty: A Retrospective Cohort Study.

Jincong Yu, Tingting Mi, Zheyuan Shao, Xuding Yan

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Orthopaedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05476367 (Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05476367 unknown statusnot on this map

Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty

TypeobservationalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2022 to 2022Enrolled614ConditionsArthritis Knee
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jincong YuDepartment of Joint and Limb Surgery, Yangming Hospital Affiliated to Ningbo University, Yuyao, Zhejiang Province, China.
Tingting MiDepartment of Joint and Limb Surgery, Yangming Hospital Affiliated to Ningbo University, Yuyao, Zhejiang Province, China.
Zheyuan ShaoDepartment of Joint and Limb Surgery, Yangming Hospital Affiliated to Ningbo University, Yuyao, Zhejiang Province, China.
Xuding YanDepartment of Joint and Limb Surgery, Yangming Hospital Affiliated to Ningbo University, Yuyao, Zhejiang Province, China.ORCID https://orcid.org/0009-0001-9200-8856

Funding

Natural Science Foundation of Zhejiang Province LY20H170002
6 · The paper itself

Abstract

objectiveHyperuricemia, characterized by elevated serum uric acid levels without acute gout symptoms, may influence postoperative outcomes after total knee arthroplasty (TKA). This study aimed to evaluate the impact of hyperuricemia on postoperative inflammatory responses, complications, and mid-term functional outcomes in patients undergoing primary TKA.

methodsThis was a retrospective cohort study. We identified all patients who had undergone primary TKA from April 1, 2015, to March 30, 2016. Patients were grouped by uric acid level. The knee society score (KSS) and hospital for special surgery knee score (HSS) before the surgery and 6 years after the surgery were recorded. Statistical analyses included t-tests, chi-square tests, and regression analyses to assess the influences of uric acid levels on C-reactive protein (CRP) levels, body temperature, functional scores, and local inflammatory response. The influence of the uric acid level on the local inflammatory response was also analyzed.

resultsOf the 614 patients, 140 had hyperuricemia, and 474 had normal uric acid levels. The hyperuricemia group had a higher unplanned readmission rate (11.4% vs. 5.7%, p < 0.05) and longer hospital stay (10.75 vs. 9.54 days, p = 0.002). CRP levels were significantly greater in the hyperuricemia group (OR = 34.64, 95% CI: 27.99-41.30, p < 0.001), and the incidence of the local inflammatory response was greater (42.1% vs. 9.5%, p < 0.01). The diagnostic accuracy for uric acid in the local inflammatory response was 0.742 (AUC). Improvements in the KSS clinical score (p < 0.01), KSS functional score (p < 0.01), and HSS score (p < 0.01) were lower in the hyperuricemia group.

conclusionsHyperuricemia is associated with significantly elevated postoperative CRP levels, a higher unplanned readmission rate, and substantially poorer mid-term functional outcomes after TKA. These patients also demonstrate increased inflammatory complications. These findings support preoperative uric acid screening to identify high-risk patients for targeted management. CLINICAL RELEVANCE: Level III.

trial registrationClinicalTrials.gov identifier: NCT05476367.

Indexed as

Arthroplasty, Replacement, KneeHyperuricemiaOsteoarthritis, KneePostoperative ComplicationsAgedCohort StudiesC-Reactive ProteinFemaleHumansMaleMiddle AgedPatient ReadmissionRetrospective StudiesTreatment OutcomeUric AcidC-Reactive ProteinUric AcidHSS scorehyperuricemiainflammatory responseknee society scoretotal knee arthroplasty

Identifiers

PMID41198532
PMCPMC12685486

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.