Evidence mapPaperPMID 41198688Full record

ReviewNPJ primary care respiratory medicine2025

A narrative review and expert opinion on immunity-targeted approaches in the management of viral upper respiratory tract infections.

Jiří Beran, Roman S Kozlov, Pavol Jarčuška, Lilla Tamási

Abstract readReview
In one paragraph

Review in NPJ primary care respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiří BeranInstitute for Postgraduate Medical Education Prague, Department for Tropical and Travel Medicine, Prague, Czechia.
Roman S KozlovSmolensk State Medical University, Smolensk, Russia.
Pavol JarčuškaDpt. of Infectious Diseases and Travel Medicine, Faculty of Medicine, Pavol Jozef Šafárik University in Košice and University Hospital of L. Pasteur in Košice, Košice, Slovakia.
Lilla TamásiSemmelweis University, Department of Pulmonology, Budapest, Hungary. tamasi.lilla@semmelweis.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upper respiratory tract infections (URTIs) are among the most common diseases encountered in primary medical care. Recurrent URTIs (RURTIs) considerably affect patient health and quality of life. Recent evidence indicates that increased attention is being paid to symptom improvement in clinical practice. However, the therapeutic opportunities associated with using a vector for improving the immune status of patients remain underestimated. As the most common sources of URTI are viral infections, antiviral agents with the potential to enhance host immune responses can be considered auxiliary, effective, and safe for children and adults with URTIs and RURTIs. This review reports the current evidence and expert opinions on immunity-targeted approaches in the management of viral URTIs. Undelayed diagnosis and initiating treatment in the early stages of URTIs are crucial elements that can significantly improve disease evolution and the overall health of patients of any age group. An immunomodulatory remedy would be optimal for facilitating the healing of acute infections, reducing recurrence and complications, antibiotic consumption, and the consequences of antibiotic overuse. Maintaining and protecting the intestinal microbiota is also an important step toward effective URTI treatment. The findings of this review provide valuable insights into the effective management of URTIs and RURTIs based on the latest clinical evidence.

Indexed as

Antiviral AgentsRespiratory Tract InfectionsVirus DiseasesHumansAntiviral Agents

Identifiers

PMID41198688
PMCPMC12592500

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.