Evidence map›Paper›PMID 41198743›Full record

ArticleScientific reports2025

FZD6 mediates the contributing role of miR-199a-5p in the adipogenesis of bone marrow mesenchymal stem cells derived from aplastic anemia.

Xianning Zhang, Huanhuan Zhang, Saisai Ren, Wenjuan Zhang, Qian Huang, Wenhui Huang, Lulu Liu, Mingkang Yao, Haihui Liu, Hao Zhang and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xianning Zhang *Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Huanhuan Zhang *Department of Operating Room, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Saisai RenDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Wenjuan ZhangDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Qian HuangDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Wenhui HuangDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Lulu LiuMedical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Mingkang YaoDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Haihui LiuDepartment of Hematology, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.
Hao ZhangKey laboratory of cell and biomedical Technology of Shandong Province, Jining, China.
Mingtai ChenMedical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China. chenmt3153@mail.jnmc.edu.cn.

Funding

National Natural Science Foundation of China 81700099Natural Science Foundation of Shandong Province, China ZR2021QH099Natural Science Foundation of Shandong Province, China ZR2022MH108Natural Science Foundation of Shandong Province, China ZR2022QH071Research Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University JYHL2021FMS09Scientific Research Cultivation Project of Jining Medical University JYGC2022FKJ006Taishan Scholars Program of Shandong Province tsqn202211367Youth Innovation Technology Project of Higher School in Shandong Province 2022KJ105
6 · The paper itself

Abstract

Accumulating evidence indicates that enhanced adipogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) derived from aplastic anemia (AA) could contribute to the excessive fat accumulation in the bone marrow. However, the underlying molecular mechanism remains to be determined. Here in this study, we further characterized the contributing role of miR-199a-5p in adipogenesis of AA BM-MSCs through specific inhibition of miR-199a-5p expression. Subsequently, we performed a systematic screening of the downstream targets of miR-199a-5p through web tool prediction, profiling data analysis, and experimental validation, with FZD6 and CELSR1 identified as the most promising targets of miR-199a-5p in the adipogenesis of AA BM-MSCs. Finally, we mainly focused on FZD6, which presents prominently decreased expression in adipogenic differentiation and AA BM-MSC samples and negatively correlates with miR-199a-5p expression. Besides, FZD6 is demonstrated as a negative regulator of adipogenesis of BM-MSCs, and overexpression of FZD6 alleviates the facilitating role of miR-199a-5p in the adipogenic differentiation of BM-MSCs. Overall, our findings provide further mechanistic insights into miR-199a-5p-mediated enhanced adipogenesis of AA BM-MSCs, implicating miR-199a-5p and FZD6 as potential intervention targets for improving BM-MSC-mediated microenvironments.

Indexed as

AdipogenesisAnemia, AplasticBone Marrow CellsFrizzled ReceptorsMesenchymal Stem CellsMicroRNAsCell DifferentiationCells, CulturedGene Expression RegulationHumansMaleFrizzled ReceptorsFZD6 protein, humanMicroRNAsmirn199 microRNA, humanAdipogenic differentiationAplastic anemiaBone marrow mesenchymal stem cellFZD6MiR-199a-5p

Identifiers

PMID41198743
PMCPMC12592451

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.