Evidence map›Paper›PMID 41198783›Full record

ArticleScientific reports2025

Synthesis, in vitro, and in silico studies of 4-chlorophenyl-sulfonyl Indole based thiosemicarbazones as competitive α-glucosidase inhibitors.

Iqra Naseer, Saeed Ullah, Zahra Batool, Mariya Al-Rashida, Talha Islam, Ajmal Khan, Javid Hussain, Ahmed Al-Harrasi, Zahid Shafiq, Ahmed Mohamed Tawfeek and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iqra NaseerInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Saeed UllahDepartment of Biology and Biochemistry, University of Houston, Houston, TX, 77004, USA.
Zahra BatoolInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Mariya Al-RashidaDepartment of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.
Talha IslamDepartment of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.
Ajmal KhanDepartment of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Javid HussainDepartment of Biological Sciences and Chemistry, University of Nizwa, Nizwa, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, PC 616, P.O. Box 33, Nizwa, Sultanate of Oman. aharrasi@unizwa.edu.om.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.
Ahmed Mohamed TawfeekDepartment of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Mohammad Shahidul IslamDepartment of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia. mislam@ksu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent need for effective and novel solutions to address the rising global epidemic of diabetes mellitus (DM) has become a priority for researchers. This chronic ailment, with its alarming prevalence and life-threatening complications (neuropathy, retinopathy and nephropathy), necessitates novel therapeutic strategies. Herein we have synthesized a novel series of N-substituted indole-based thiosemicarbazone derivatives 5(a-y) and explored their potential as α-glucosidase inhibitors. All the compounds displayed excellent inhibitory potential with IC

Indexed as

alpha-GlucosidasesGlycoside Hydrolase InhibitorsIndolesThiosemicarbazonesCatalytic DomainHumansHypoglycemic AgentsMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity Relationshipalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsIndolesThiosemicarbazones4-chlorophenyl-sulfonyl indoleGlucosidaseIn silicoKineticsMolecular docking

Identifiers

PMID41198783
PMCPMC12592486

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.