Evidence map›Paper›PMID 41199019›Full record

ArticleAAPS PharmSciTech2025

Injectable Hyaluronic Acid Hydrogels Crosslinked by Structure-engineered Aldehyde-functionalized β-Cyclodextrin Derivatives for Long-term Controlled Voriconazole Delivery.

Chao Yang, Meng Xin, Yufu Jiang, Wenqian Wang, Wenhui Li, Junlin Quan, Wancong Zhou, Rui Yuan, Zhe Chen, Depeng Shi and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chao YangCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0000-0001-9150-0657
Meng XinYantai Affiliated Hospital of Binzhou Medical University, Yantai, 264100, Shandong, China.ORCID http://orcid.org/0009-0000-4370-0937
Yufu JiangCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0009-0001-7550-4866
Wenqian WangShangdong Dongyue Research Institute Co., Ltd, Zibo, 255000, Shandong, China.
Wenhui LiCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0009-0007-2448-802X
Junlin QuanCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0009-0001-3002-4578
Wancong ZhouCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0009-0005-7550-6799
Rui YuanCollege of Textiles&Clothing, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0009-0006-2164-0439
Zhe ChenCollege of Materials Science and Engineering, Qingdao University of Science & Technology, Qingdao, 266042, Shandong, China.ORCID http://orcid.org/0009-0001-6652-4443
Depeng ShiEye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0000-0001-5647-8917
Zhijian JiSchool of Automation, Qingdao University, Qingdao, 266071, Shandong, China.ORCID http://orcid.org/0000-0002-9666-2572
Xingxing YueCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China. yuexx90@163.com.ORCID http://orcid.org/0009-0004-2298-3674
Guojun SongCollege of Materials Science and Engineering, Qingdao University, Qingdao, 266071, Shandong, China. songguojunqdu@126.com.ORCID http://orcid.org/0000-0001-6614-3395

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term controlled release in drug-loaded injectable hydrogels is challenging in the injection-based treatments of ocular diseases. Herein, injectable hyaluronic acid (HA)-based hydrogels were synthesized in situ via Schiff base reaction between amino-functionalized hyaluronic acid (NHA) and three aldehyde-functionalized β-cyclodextrin (β-CD) derivatives: aldehyde β-cyclodextrin (ACD), aldehyde linear poly-β-cyclodextrin (ALCD), and aldehyde branched poly-β-cyclodextrin (ABCD). The composition, structure, and properties of the prepared hydrogels were analyzed using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and dynamic rheometry. The hydrogels exhibited a pore size range of 50-250 μm, a swelling degree of 27.1-45.0%, and a gelation time of 60-300 s, demonstrating suitable microstructural and rheological properties for clinical applications. By leveraging the dual functionality of the aldehyde β-CD derivatives as both crosslinking agents and drug carriers (Voriconazole (VCZ) was as a model drug), the hydrogels achieved long-term controlled release (> 60 days) with quasi-zero-order kinetics in the later stage, alongside excellent cellular compatibility, particularly for NHA/ACD (R

Indexed as

Aldehydesbeta-CyclodextrinsHyaluronic AcidHydrogelsVoriconazoleAnimalsCross-Linking ReagentsDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsDrug LiberationInjectionsRheologySpectroscopy, Fourier Transform InfraredAldehydesbeta-CyclodextrinsbetadexCross-Linking ReagentsDelayed-Action PreparationsDrug CarriersHyaluronic AcidHydrogelsVoriconazoleAldehyde poly-β-cyclodextrinDrug deliveryInjectable hydrogelSchiff baseVoriconazole

Identifiers

PMID41199019

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.