Evidence map›Paper›PMID 41199096›Full record

ArticleChinese journal of integrative medicine2026

Effect and Mechanism of Cerebrovasodilation Induced by Total Flavonoids of Chuzhou Chrysanthemum in Rats.

Xiao Wang, Miao Wu, Yu-Wen Li, Xing-Yu Zhang, Yong-Feng Cheng, Ji-Yue Wen, Shuo Chen, Zhi-Wu Chen

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Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao WangDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China.
Miao WuDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China.
Yu-Wen LiDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China.
Xing-Yu ZhangDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China.
Yong-Feng ChengClinical Medical College, Anhui Medical University, Hefei, 230012, China.
Ji-Yue WenDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China.
Shuo ChenKey Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230038, China.
Zhi-Wu ChenDepartment of Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Hefei, 230032, China. chpharmzw@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate cerebral vasorelaxation of total flavonoids of Chuzhou chrysanthemum (TFCC) in rats and its mechanism.

methodsCerebral basilar arteries (CBA) of rats were isolated, and the vasodilation induced by TFCC (10-2,560 mg/L) following pretension with 100 nmol/L U

resultsTFCC caused a concentration-dependent vasorelaxation in the rat CBA precontracted with KCl or U

conclusionsTFCC dilated rat CBA in both endothelium-dependent and -independent manner. Its endothelium-dependent dilation was probably involved in the blockade of L-type Ca

Indexed as

ChrysanthemumDrugs, Chinese HerbalFlavonoidsVasodilationVasodilator AgentsAnimalsBasilar ArteryCalciumEndothelial CellsMaleRatsRats, Sprague-DawleyCalciumDrugs, Chinese HerbalFlavonoidsVasodilator AgentscerebrovasodilationChinese medicineendothelial H2Slarge-conductance calcium-activated potassium channelL-type Ca2+ channeltotal flavonoids of Chuzhou chrysanthemum

Identifiers

PMID41199096

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.