Evidence mapPaperPMID 41199149Full record

ReviewAnimal models and experimental medicine2025

Animal models of hypertension and concurrent organs injury.

Ye Wang, Xiaoliang Jiang, Zhiwei Yang

Abstract readReview
In one paragraph

Review in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Animal models of hypertension and concurrent organs injury.Animal models and experimental medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ye WangNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, P.R. China.
Xiaoliang JiangNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, P.R. China.
Zhiwei YangNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, P.R. China.

Funding

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CAMS) 2021-1-I2M-035Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CAMS) 2021-I2M-1-035Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CAMS) 2021-I2M-1-072National Natural Science Foundation of China 82270289the National key research and development program 2022YFF0710600
6 · The paper itself

Abstract

Although hypertension is a frequently seen chronic condition across the world, its exact cause remains unclear. Animal models are beneficial for clarifying the pathogenic mechanism of hypertension and examining new treatments. An optimal animal model for studies on hypertension must well mimic human-like hemodynamics and pathophysiological structural modification, showing human disease features and complications timely or even ahead of time. A review of the most frequently used hypertensive animal models available, including small and large animals, induced and genetic models, would provide an insight into the appropriate targets to be addressed in the development of different hypertensive animal models. Another focus of the review are the processes of target-organs injury caused by high blood pressure, which mainly influences human health.

Indexed as

Disease Models, AnimalHypertensionAngiotensin IIAnimalsModels, GeneticAngiotensin IIanimalgenetic modelhypertensionorgan damage

Identifiers

PMID41199149
PMCPMC12660497

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.