SynthesisMalaria journal2025
High-throughput screening and meta-analysis for lead compounds in antimalarial drug discovery.
Synthesis in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
14 authors.
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Abstract
backgroundThe discovery of novel antimalarial drugs against Plasmodium falciparum has become globally urgent due to the consistent increase in mortality, morbidity, and drug resistance in endemic areas.
methodsUsing an in-house library, novel antimalarial agents were identified through in vitro high-throughput screening (HTS) and meta-analysis. Hit compounds were selected from the primary HTS at 10 µM and confirmed in a dose-dependent manner to determine their IC₅₀ values. The identified hit molecules were further selected based on the following criteria: novelty, antimalarial activity (IC
resultsBased on the top 3% threshold, 256 compounds were selected for dose‒response curve analysis from the HTS. Among them, 110 compounds without published research related to Plasmodium and 157 compounds with IC
conclusionsCombining HTS and meta-analysis provides a robust method for screening antimalarial candidate compounds and identifying new hits with in vivo activity as candidates to treat drug-resistant malarial strains.
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