ReviewCNS neuroscience & therapeutics2025
Acupuncture's Multisystem Neuroimmunomodulation: Central-Peripheral Interactions in Gastroenteric, Psychiatric, and Chronic Pain Disorders.
Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Efficacy of Superficial Acupuncture Stimulation with Dynamic Mobilization in Chronic Neck Pain: A Multicenter Randomized Controlled Trial.Journal of pain research · 2026Trial
- Personalized Treatments for Functional Disorders of the Sphincter of Oddi: A Short Muscle with a Long History of Discussion and Controversies.Journal of personalized medicine · 2026Review
- Progress in the Treatment of Adhesive Capsulitis with External Therapies of Traditional Chinese Medicine: A Comprehensive Review.Journal of pain research · 2026Review
- Acupuncture as a potential host-directed therapeutic strategy in neuroinfectious diseases: a neuroimmune mechanistic perspective.Frontiers in medicine · 2026Article
- Progress in traditional Chinese medicine for chemotherapy-induced nausea and vomiting, based on the theory of "Fuzheng Quxie" and "Hewei Jiangni".American journal of translational research · 2026Review
- Acupuncture's Multisystem Neuroimmunomodulation: Central-Peripheral Interactions in Gastroenteric, Psychiatric, and Chronic Pain Disorders.CNS neuroscience & therapeutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundAcupuncture, an ancient therapeutic modality rooted in traditional Chinese medicine, has evolved into a globally recognized intervention. Mounting evidence indicates that modulation of central-peripheral interactions constitutes a key pathophysiological mechanism underlying its efficacy. This review examines how acupuncture bridges neural, immune, and endocrine systems through these dynamic interactions to address complex modern diseases.
methodsWe integrate cutting-edge advances from neuroimaging and mechanistic studies to elucidate acupuncture's mechanisms targeting central-peripheral crosstalk. Three paradigmatic conditions-functional gastrointestinal disorders, psychiatric disorders, and chronic pain-are employed to dissect its systemic effects.
resultsAcupuncture consistently demonstrates therapeutic benefits across paradigms through multisystem modulation. Core mechanisms include: neural circuitry dynamics (brain-gut/sensory axis regulation), neuro-immune-endocrine integration (cytokine-HPA-glial signaling), and humoral network modulation (hormone/metabolite-mediated cross-talk). These actions remodel complex pathophysiological networks, translating into improved clinical outcomes.
conclusionsAcupuncture emerges as an integrative therapy with a robust scientific foundation in systems biology. Future research leveraging omics and neuroimaging should focus on developing precision protocols targeting individual genetic, epigenetic, and connectomic profiles. This evolution holds significant promise for advancing integrative neurology and expanding the application of acupuncture against complex diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.