ArticleAnnals of gastroenterological surgery2025
Impact of Ghrelin-Depleting Gastrectomy on Long-Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content.
Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Advances in diagnostic and surgical techniques have improved survival rates for gastric cancer patients. However, gastrectomy involving ghrelin-secreting regions of the upper gastric greater curvature can lead to long-term endocrine and metabolic disturbances, including reductions in serum ghrelin and insulin-like growth factor-1 (IGF-1), potentially contributing to skeletal muscle and bone mineral loss. Methods: This prospective observational study included 35 gastric cancer patients who underwent gastrectomy between 2016 and 2018, with follow-up for 3-5 years. Patients were categorized into ghrelin-depleted (total or proximal gastrectomy) and ghrelin-preserved (distal gastrectomy) groups. Serum desacyl-ghrelin, IGF-1, and insulin-like growth factor-binding protein-3 (IGFBP-3) levels were measured, and skeletal muscle mass and bone mineral content were assessed. Results: The ghrelin-depleted group exhibited significantly lower serum desacyl-ghrelin (56.9 ± 27.9 vs. 111.2 ± 54.8 fmol/mL, Conclusion: Gastrectomy involving resection of ghrelin-rich regions leads to long-term reductions in serum desacyl-ghrelin levels, adversely affecting skeletal muscle mass and bone mineral content. These findings highlight the importance of considering the endocrine consequences when selecting surgical procedures.
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