ReviewOpen veterinary journal2025
Polysulfated glycosaminoglycan as a treatment for osteoarthritis in veterinary medicine: Summary of the pharmacological, laboratory, and clinical data.
Review in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
1 author.
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Abstract
Polysulfated glycosaminoglycan (PSGAG) is an antiarthritic drug that has been used in veterinary medicine for many years. PSGAG is rapidly distributed to diseased joint tissue after intraarticular or intramuscular administration, as shown in pharmacological studies conducted on a variety of animal species. In diseased joint tissue, PSGAG stimulates: 1) its own incorporation into the cartilage matrix, 2) inhibition of catabolic enzymes, 3) anabolic effects in the synovial and cartilage tissue, and 4) anti-inflammatory effects. Laboratory and clinical studies in humans, rabbits, horses, and dogs have shown reduced severity of clinical signs and beneficial biochemical and morphological effects in inflamed or damaged joints. The drug has minimal side effects and adverse reactions in horses and dogs. Due to the above findings, PSGAG has been classified as a disease modifying osteoarthritis drug (DMOAD), and the drug remains a popular treatment for synovial inflammation and osteoarthritis in horses and dogs. Herein, we review the experimental and clinical evidence that led PSGAG to its classification as a DMOAD.
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