Evidence map›Paper›PMID 41200880›Full record

ArticlePlant biotechnology journal2026

Transcriptional Regulation of SWEET15_A01 by MYB44/bHLH3 Modulates Carbon Allocation in Cotton Ovule and Fibre to Affect Seed and Fibre Traits.

Yu Le, Meilin Chen, De Zhu, Zhiyong Xu, Chao Fu, Xinhui Xiong, Yuanxue Li, Ningyu Yang, Liuyang Hui, Xianlong Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu LeNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Meilin ChenNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
De ZhuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.
Zhiyong XuNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Chao FuNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Xinhui XiongNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Yuanxue LiNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Ningyu YangNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Liuyang HuiNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Xianlong ZhangNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-7703-524X
Zhongxu LinNational Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-8537-4890

Funding

National Key Research and Development Program of China 2023YFD2301200National Natural Science Foundation of China 32172025
6 · The paper itself

Abstract

The allocation of carbon sources between cotton ovule and fibre significantly influences the yield and quality of seed and fibre. SWEET15 (Sugars Will Eventually be Exported Transporter 15) plays a key role in sucrose transport; however, the transcriptional regulation of SWEET15 in cotton remains unclear. Here, a SWEET15_A01, predominantly expressed during late ovule development (25-35 DPA), functions as a sucrose transporter between the ovule and fibre in cotton. Promoter variations between sea-island and upland cottons correlate with differential expression and cottonseed oil content. Overexpressing SWEET15_A01 in upland cotton reduces fibre length, seed size and oil content but increases lint percentage. Downregulation of SWEET15_A01 in upland cotton ovules upregulates other sugar transporters and cellulose synthase genes (CesAs) in fibres, indicating compensatory mechanisms. The R2R3-MYB transcription factor MYB44 directly binds to the SWEET15_A01 promoter, suppressing its expression, while bHLH3 interacts with MYB44 to weaken this repression. Overexpressing MYB44 increases fibre length but reduces seed size and oil content. This study reveals genetic variations for cottonseed oil improvement and elucidates how the MYB44/bHLH3-SWEET15_A01 module coordinates sugar allocation to balance seed and fibre development, offering strategies for enhancing cottonseed oil content.

Indexed as

Basic Helix-Loop-Helix ProteinsCarbonCotton FiberGossypiumOvulePlant ProteinsSeedsTranscription FactorsGene Expression Regulation, PlantPromoter Regions, GeneticBasic Helix-Loop-Helix ProteinsCarbonPlant ProteinsTranscription Factorscotton ovule and fibre developmentcottonseed oilMYB44sugar allocationSWEET15_A01

Identifiers

PMID41200880
PMCPMC12946506

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.